Cytostatic anticancer activity of novel C^N^N platinum (II) carbene-containing complexes – New mitochondrial uncouplers

IF 4 2区化学 Q2 CHEMISTRY, PHYSICAL

Journal of Molecular Structure Pub Date : 2025-03-24 DOI:10.1016/j.molstruc.2025.142158

Maria D. Tokhtueva , Vladislav M. Abramov , Vsevolod V. Melekhin , Ekaterina S. Sheina , Sergey L. Deev , Oleg S. Eltsov

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Abstract

In this work, we lead to the appearance of novel carbene-containing C^N^N platinum (II) complexes of arylbipyridines. This paper describes the synthesis, structure properties, and outcomes of an in vitro cytotoxicity research. The synthesized metal complexes exhibit broad anticancer efficacy against cell lines such as human glioblastoma A172, lung carcinoma A549 and liver carcinoma HepG2. The average inhibitory doses obtained using the MTT test are many times greater than the Cisplatin activity concentrations currently used in medical practice. The experiment involving Annexin V-FITC and propidium iodide revealed that apoptotic processes of cell death were not induced. Additionally, several platinum complexes were found to have a strong cytostatic impact and to impede replication. It was discovered that novel compounds containing carbenes result in a reduction in mitochondrial potential equivalent to that of the positive control when cells were stained with JC-1 dye. We have found that the main antitumor mechanism of action of platinum complex compounds is due to a complete drop in potential on mitochondria and a slowdown in cell division.

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来源期刊

Journal of Molecular Structure 化学-物理化学

CiteScore

7.10

自引率

15.80%

发文量

2384

审稿时长

45 days

期刊介绍： The Journal of Molecular Structure is dedicated to the publication of full-length articles and review papers, providing important new structural information on all types of chemical species including: • Stable and unstable molecules in all types of environments (vapour, molecular beam, liquid, solution, liquid crystal, solid state, matrix-isolated, surface-absorbed etc.) • Chemical intermediates • Molecules in excited states • Biological molecules • Polymers. The methods used may include any combination of spectroscopic and non-spectroscopic techniques, for example: • Infrared spectroscopy (mid, far, near) • Raman spectroscopy and non-linear Raman methods (CARS, etc.) • Electronic absorption spectroscopy • Optical rotatory dispersion and circular dichroism • Fluorescence and phosphorescence techniques • Electron spectroscopies (PES, XPS), EXAFS, etc. • Microwave spectroscopy • Electron diffraction • NMR and ESR spectroscopies • Mössbauer spectroscopy • X-ray crystallography • Charge Density Analyses • Computational Studies (supplementing experimental methods) We encourage publications combining theoretical and experimental approaches. The structural insights gained by the studies should be correlated with the properties, activity and/ or reactivity of the molecule under investigation and the relevance of this molecule and its implications should be discussed.