Mitochondria-localized iridium(III) complexes as chemotherapeutic agents against melanoma

IF 2.4 3区化学 Q2 CHEMISTRY, INORGANIC & NUCLEAR

Polyhedron Pub Date : 2025-04-01 DOI:10.1016/j.poly.2025.117527

Ziyang Liu , Qixuan Zhang , Yixiong Yang , Ruochen Li , Xiyao Liu , Qingyi Lin , Zhanghui Zhu , Zhuohuai Gao , Tao Feng , Tianfang Cheng , Jian Wang , Hui Chao

引用次数: 0

Abstract

Chemotherapy remains the mainstay of cancer treatment. There is a growing propensity to design and develop drugs with structural complexity to enhance therapeutic efficacy. However, complex structures are complicated to prepare and are prone to uncertainties. On the contrary, simplifying structures is a practical approach to clarifying the treatment effect and the success of drug design. Herein, we design three cyclometalated Ir(III) complexes with simple structures that target the mitochondria to induce cell apoptosis. Briefly, the Ir(III) complexes can target mitochondria and cause mitochondrial damage by disrupting mitochondrial membrane potential, which activates the Caspase 3/7-dependent apoptotic pathway and thus inhibits melanoma at cellular. Therefore, constructing simple structural metal complexes offers a promising strategy for treating cancer.

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来源期刊

Polyhedron 化学-晶体学

CiteScore

4.90

自引率

7.70%

发文量

515

审稿时长

2 months

期刊介绍： Polyhedron publishes original, fundamental, experimental and theoretical work of the highest quality in all the major areas of inorganic chemistry. This includes synthetic chemistry, coordination chemistry, organometallic chemistry, bioinorganic chemistry, and solid-state and materials chemistry. Papers should be significant pieces of work, and all new compounds must be appropriately characterized. The inclusion of single-crystal X-ray structural data is strongly encouraged, but papers reporting only the X-ray structure determination of a single compound will usually not be considered. Papers on solid-state or materials chemistry will be expected to have a significant molecular chemistry component (such as the synthesis and characterization of the molecular precursors and/or a systematic study of the use of different precursors or reaction conditions) or demonstrate a cutting-edge application (for example inorganic materials for energy applications). Papers dealing only with stability constants are not considered.