The Hallmarks of Cancer as Eco-Evolutionary Processes

IF 29.7 1区医学 Q1 ONCOLOGY

Cancer discovery Pub Date : 2025-04-02 DOI:10.1158/2159-8290.cd-24-0861

Ranjini Bhattacharya, Stanislav S. Avdieiev, Anuraag Bukkuri, Christopher J. Whelan, Robert A. Gatenby, Kenneth Y. Tsai, Joel S. Brown

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引用次数: 0

Abstract

The “Hallmarks of Cancer” represent characteristics of neoplastic cells. Hanahan and Weinberg noted that the acquisition of these hallmarks mimics Darwinian evolution. In this study, we deconstruct the hallmarks “color wheel” into linear, parallel, and interlinked stages: cancer initiation, evolving evolvability, niche construction, adaptations for safety, and emergent phenomenon. During carcinogenesis, a cell evolves from being part of the organism into an autonomous unit subject to natural selection. The hallmark traits enable this transition, representing adaptations for survival within their tumor ecosystem. Unwinding the hallmarks color wheel and viewing them as eco-evolutionary processes provide a unifying framework for defining, understanding, and treating cancer. Significance: Viewing the hallmarks as a sequence of adaptations captures the “why” behind the “how” of the molecular changes driving cancer. This eco-evolutionary view distils the complexity of cancer progression into logical steps, providing a framework for understanding all existing and emerging hallmarks of cancer and developing therapeutic interventions.

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癌症作为生态进化过程的特征

“肿瘤标志”代表肿瘤细胞的特征。Hanahan和Weinberg指出，这些特征的获得模仿了达尔文的进化。在本研究中，我们将标志性的“色轮”解构为线性、平行和相互关联的阶段：癌症起始、进化进化、生态位构建、安全适应和突现现象。在癌变过程中，细胞从机体的一部分进化为自然选择下的独立单位。这些标志性的特征使这种转变成为可能，代表了它们在肿瘤生态系统中生存的适应性。解开标志色轮并将其视为生态进化过程，为定义、理解和治疗癌症提供了一个统一的框架。意义：将这些特征视为一系列适应，抓住了驱动癌症的分子变化背后的“为什么”。这种生态进化观点将癌症进展的复杂性提炼成逻辑步骤，为理解所有现有和新出现的癌症特征和开发治疗干预提供了一个框架。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer discovery ONCOLOGY-

CiteScore

22.90

自引率

1.40%

发文量

838

审稿时长

6-12 weeks

期刊介绍： Cancer Discovery publishes high-impact, peer-reviewed articles detailing significant advances in both research and clinical trials. Serving as a premier cancer information resource, the journal also features Review Articles, Perspectives, Commentaries, News stories, and Research Watch summaries to keep readers abreast of the latest findings in the field. Covering a wide range of topics, from laboratory research to clinical trials and epidemiologic studies, Cancer Discovery spans the entire spectrum of cancer research and medicine.