How 5-ALA enlightens neurosurgery - results of a single centre study on high-grade gliomas.

IF 1.3 4区 医学 Q4 ENVIRONMENTAL SCIENCES
Marek Mazurek, Natalia Lehman, Filip Stoma, Gabriela Czaja, Agata Banach, Bożena Jarosz, Radosław Rola
{"title":"How 5-ALA enlightens neurosurgery - results of a single centre study on high-grade gliomas.","authors":"Marek Mazurek, Natalia Lehman, Filip Stoma, Gabriela Czaja, Agata Banach, Bożena Jarosz, Radosław Rola","doi":"10.26444/aaem/194075","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction and objective: </strong>This study aims to assess the effectiveness of the use of intraoperative fluorescence with 5-ALA on the scope on the resection and the results of the treatment of patients. Despite the continuous development of new oncological treatments, surgical resection remains the basis for treating high-grade gliomas. For this reason, methods are introduced to facilitate the removal of the tumour in a maximally complete and safe manner for the patient.</p><p><strong>Material and methods: </strong>The effects were examined of intraoperative fluorescence using 5-aminolevulinic acid (5-ALA). The volumetric extent of resection and the outcome of 39 cases of patients with high-grade gliomas operated on using intraoperative fluorescence were compared with 5-ALA and patients undergoing resection using a white-light microscope.</p><p><strong>Results: </strong>The use of 5-ALA during the procedure increased the extent of resection compared to procedures under white light: - 96.14% vs. 90.69%. Interestingly, when focused on recurrent high-grade gliomas, better results were observed for the white-light group. There was also an improvement in the overall survival (OS) of patients operated on with 5-ALA (p=0.0485). OS for the study group was 9.97 months compared to 6.40 months for the control group.</p><p><strong>Conclusions: </strong>Based on the observations, the use of 5-ALA in surgery for high-grade gliomas allows for an increase in the extent of resection performed and an improvement in patient prognosis. Moreover, the use of 5-ALA shows better results for primary tumours when compared to recurrent ones (p<0.0001 for primary gliomas).</p>","PeriodicalId":50970,"journal":{"name":"Annals of Agricultural and Environmental Medicine","volume":"32 1","pages":"133-141"},"PeriodicalIF":1.3000,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals of Agricultural and Environmental Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.26444/aaem/194075","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/10/15 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"ENVIRONMENTAL SCIENCES","Score":null,"Total":0}
引用次数: 0

Abstract

Introduction and objective: This study aims to assess the effectiveness of the use of intraoperative fluorescence with 5-ALA on the scope on the resection and the results of the treatment of patients. Despite the continuous development of new oncological treatments, surgical resection remains the basis for treating high-grade gliomas. For this reason, methods are introduced to facilitate the removal of the tumour in a maximally complete and safe manner for the patient.

Material and methods: The effects were examined of intraoperative fluorescence using 5-aminolevulinic acid (5-ALA). The volumetric extent of resection and the outcome of 39 cases of patients with high-grade gliomas operated on using intraoperative fluorescence were compared with 5-ALA and patients undergoing resection using a white-light microscope.

Results: The use of 5-ALA during the procedure increased the extent of resection compared to procedures under white light: - 96.14% vs. 90.69%. Interestingly, when focused on recurrent high-grade gliomas, better results were observed for the white-light group. There was also an improvement in the overall survival (OS) of patients operated on with 5-ALA (p=0.0485). OS for the study group was 9.97 months compared to 6.40 months for the control group.

Conclusions: Based on the observations, the use of 5-ALA in surgery for high-grade gliomas allows for an increase in the extent of resection performed and an improvement in patient prognosis. Moreover, the use of 5-ALA shows better results for primary tumours when compared to recurrent ones (p<0.0001 for primary gliomas).

5-ALA 如何启迪神经外科--单中心高级别胶质瘤研究结果。
前言与目的:本研究旨在评价术中荧光联合5-ALA对肿瘤切除范围及患者治疗效果的影响。尽管新的肿瘤治疗方法不断发展,手术切除仍然是治疗高级别胶质瘤的基础。出于这个原因,引入了一些方法来促进以最大限度地完整和安全的方式对患者切除肿瘤。材料和方法:观察5-氨基乙酰丙酸(5-ALA)对术中荧光的影响。对39例高级别胶质瘤患者术中荧光与5-ALA、白光显微镜下切除术患者的体积切除范围及预后进行比较。结果:与白光下手术相比,手术中使用5-ALA增加了切除范围:- 96.14%对90.69%。有趣的是,当聚焦于复发的高级别胶质瘤时,白光组观察到更好的结果。5-ALA手术患者的总生存率(OS)也有改善(p=0.0485)。研究组的OS为9.97个月,而对照组为6.40个月。结论:根据观察,在高级别胶质瘤的手术中使用5-ALA可以增加切除的范围并改善患者预后。此外,与复发性肿瘤相比,使用5-ALA治疗原发性肿瘤的效果更好
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Annals of Agricultural and Environmental Medicine
Annals of Agricultural and Environmental Medicine 医学-公共卫生、环境卫生与职业卫生
CiteScore
3.00
自引率
5.90%
发文量
58
审稿时长
4-8 weeks
期刊介绍: All papers within the scope indicated by the following sections of the journal may be submitted: Biological agents posing occupational risk in agriculture, forestry, food industry and wood industry and diseases caused by these agents (zoonoses, allergic and immunotoxic diseases). Health effects of chemical pollutants in agricultural areas , including occupational and non-occupational effects of agricultural chemicals (pesticides, fertilizers) and effects of industrial disposal (heavy metals, sulphur, etc.) contaminating the atmosphere, soil and water. Exposure to physical hazards associated with the use of machinery in agriculture and forestry: noise, vibration, dust. Prevention of occupational diseases in agriculture, forestry, food industry and wood industry. Work-related accidents and injuries in agriculture, forestry, food industry and wood industry: incidence, causes, social aspects and prevention. State of the health of rural communities depending on various factors: social factors, accessibility of medical care, etc.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信