Functional connectotomy of a whole-brain model reveals tumor-induced alterations to neuronal dynamics in glioma patients.

IF 3.6 3区 医学 Q2 NEUROSCIENCES
Network Neuroscience Pub Date : 2025-03-20 eCollection Date: 2025-01-01 DOI:10.1162/netn_a_00426
Christoffer G Alexandersen, Linda Douw, Mona L M Zimmermann, Christian Bick, Alain Goriely
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引用次数: 0

Abstract

Brain tumors can induce pathological changes in neuronal dynamics that are reflected in functional connectivity measures. Here, we use a whole-brain modeling approach to investigate pathological alterations to neuronal activity in glioma patients. By fitting a Hopf whole-brain model to empirical functional connectivity, we investigate glioma-induced changes in optimal model parameters. We observe considerable differences in neuronal dynamics between glioma patients and healthy controls, both on an individual and population-based level. In particular, model parameter estimation suggests that local tumor pathology causes changes in brain dynamics by increasing the influence of interregional interactions on global neuronal activity. Our approach demonstrates that whole-brain models provide valuable insights for understanding glioma-associated alterations in functional connectivity.

全脑模型的功能性连接切断术揭示了胶质瘤患者神经动力学的肿瘤诱导改变。
脑肿瘤可以诱导神经元动力学的病理改变,这反映在功能连接测量中。在这里,我们使用全脑建模方法来研究神经胶质瘤患者神经元活动的病理改变。通过将Hopf全脑模型拟合到经验功能连接中,我们研究了胶质瘤诱导的最佳模型参数的变化。我们观察到神经胶质瘤患者和健康对照之间在个体和群体水平上的神经元动力学有相当大的差异。特别是,模型参数估计表明,局部肿瘤病理通过增加区域间相互作用对全局神经元活动的影响而引起脑动力学的变化。我们的方法表明,全脑模型为理解胶质瘤相关的功能连接改变提供了有价值的见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Network Neuroscience
Network Neuroscience NEUROSCIENCES-
CiteScore
6.40
自引率
6.40%
发文量
68
审稿时长
16 weeks
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