The Interplay between Asthma, Obesity, and Obstructive Sleep Apnea.

IF 2.3 3区 医学 Q2 CRITICAL CARE MEDICINE
Lucia R Rodriguez, Sunita Sharma
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引用次数: 0

Abstract

The interrelationship between asthma, obesity, and obstructive sleep apnea (OSA) presents a critical area of investigation within sleep medicine, given the rising prevalence of these conditions globally. This article explores the multifactorial interactions among these three disorders that contribute to significant morbidity. Asthma, a chronic inflammatory condition of the airways, is one of the most common chronic respiratory conditions globally. Asthma in people with obesity is associated with poor asthma control, increased asthma severity, and an increased frequency of exacerbations. Obesity, characterized by excessive fat accumulation, is a well-established risk factor for the development of OSA. This sleep-related breathing disorder disrupts airflow during sleep due to pharyngeal collapse. Conversely, OSA may worsen asthma symptoms through intermittent hypoxia and sleep fragmentation, further complicating asthma management. This review analyzes existing literature to illustrate the bidirectional relationships among these conditions. It discusses the role of systemic inflammation, hormone dysregulation, and lifestyle factors, such as diet and physical inactivity, in the development and persistence of asthma and OSA in obese patients. Furthermore, it highlights the importance of comprehensive management strategies that address these overlapping disorders. Clinical implications are examined, with consideration given to the potential for targeted therapies and lifestyle interventions that could mitigate symptoms and improve the quality of life for affected individuals. Understanding these complex interactions is essential for healthcare practitioners in optimizing the management of patients with asthma, obesity, and OSA. By recognizing the interconnectedness of these conditions, clinicians can adopt a more holistic approach to treatment, leading to improved outcomes and a better understanding of the patient's overall health trajectory. Future research directions are suggested to investigate potential therapeutic interventions and the influence of socioeconomic factors on these chronic conditions.

哮喘、肥胖和阻塞性睡眠呼吸暂停之间的相互作用。
鉴于全球范围内哮喘、肥胖和阻塞性睡眠呼吸暂停(OSA)的患病率不断上升,哮喘、肥胖和阻塞性睡眠呼吸暂停(OSA)之间的相互关系是睡眠医学研究的一个关键领域。本文探讨了这三种疾病之间的多因素相互作用,这些疾病导致了显著的发病率。哮喘是一种呼吸道慢性炎症,是全球最常见的慢性呼吸系统疾病之一。肥胖患者的哮喘与哮喘控制不良、哮喘严重程度增加和发作频率增加有关。以过度脂肪堆积为特征的肥胖是公认的OSA发生的危险因素。这种与睡眠有关的呼吸障碍是由于咽部塌陷导致睡眠时气流紊乱。相反,OSA可通过间歇性缺氧和睡眠破碎加重哮喘症状,进一步使哮喘管理复杂化。本文对现有文献进行分析,以说明这些条件之间的双向关系。它讨论了全身性炎症、激素失调和生活方式因素,如饮食和缺乏体育活动,在肥胖患者哮喘和阻塞性睡眠呼吸暂停的发展和持续中的作用。此外,它强调了解决这些重叠疾病的综合管理战略的重要性。研究了临床影响,并考虑了靶向治疗和生活方式干预的潜力,这些治疗和干预可以减轻症状并改善受影响个体的生活质量。了解这些复杂的相互作用对于医疗保健从业者优化哮喘、肥胖和OSA患者的管理至关重要。通过认识到这些疾病的相互联系,临床医生可以采用更全面的治疗方法,从而改善结果,更好地了解患者的整体健康轨迹。未来的研究方向是探讨潜在的治疗干预措施和社会经济因素对这些慢性疾病的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
6.10
自引率
0.00%
发文量
87
审稿时长
6-12 weeks
期刊介绍: The journal focuses on new diagnostic and therapeutic procedures, laboratory studies, genetic breakthroughs, pathology, clinical features and management as related to such areas as asthma and other lung diseases, critical care management, cystic fibrosis, lung and heart transplantation, pulmonary pathogens, and pleural disease as well as many other related disorders.The journal focuses on new diagnostic and therapeutic procedures, laboratory studies, genetic breakthroughs, pathology, clinical features and management as related to such areas as asthma and other lung diseases, critical care management, cystic fibrosis, lung and heart transplantation, pulmonary pathogens, and pleural disease as well as many other related disorders.
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