Association between Metabolic Syndrome Score and Subclinical Atherosclerosis.

IF 1.9 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS
Reviews in cardiovascular medicine Pub Date : 2025-03-12 eCollection Date: 2025-03-01 DOI:10.31083/RCM26811
Ming Yi, Xinyi Wang, Yan Li, Xuewen Li, Jin Si, Yinghua Zhang, Keling Xiao, Lijie Sun, Haoyu Zhang, Jinghao Sun, Zhaoli Liu, Jiaying Lin, Yuxin Xie, Bingyan Zhang, Jing Zhao, Xi Chu, Jing Li
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引用次数: 0

Abstract

Background: Previous studies have presented conflicting results on the correlation between metabolic syndrome (MetS) and subclinical atherosclerosis. However, the binary MetS definition cannot reflect the severity of metabolic disorders continuously and dynamically. The present study calculated the MetS score and explored the association between MetS score and subclinical atherosclerosis.

Methods: A total of 840 participants were included in this observational, cross-sectional study; 66.55% of participants were men, and the median age was 61.00 years (53.00, 67.00). Brachial-ankle pulse wave velocity (baPWV) and brachial flow-mediated dilation (bFMD) values were measured from October 2016 to January 2020. Spearman's correlation and multiple linear regression analyses were conducted to explore the correlation between the MetS score and baPWV and bFMD. Arterial stiffness was defined as baPWV ≥1400 cm/s, while endothelial dysfunction was described as bFMD >6%. Multiple logistic regression was performed to explore the effects of MetS and MetS score on arterial stiffness and endothelial dysfunction.

Results: The MetS score was significantly associated with baPWV (β = 73.59, 95% CI (42.70, 104.48); p < 0.001) and bFMD (β = -0.43, 95% CI (-0.75, -0.10); p = 0.010) after adjusting for covariates. Compared with the binary definition of MetS, the MetS score was a more significant predictor for arterial stiffness (odds ratio, OR = 2.63, 95% CI (1.85, 3.74); p < 0.001) and endothelial dysfunction (OR = 1.33, 95% CI (1.01, 1.76); p = 0.040). Leukocyte count (r = 0.32; p < 0.001) and high-sensitivity C-reactive protein (hs-CRP) (r = 0.17; p < 0.001) values were related to the MetS score.

Conclusions: The MetS score is a clinically accessible assessment of metabolic status that can identify individuals at higher risk of subclinical atherosclerosis.

代谢综合征评分与亚临床动脉粥样硬化的关系
背景:以往的研究对代谢综合征(MetS)与亚临床动脉粥样硬化之间的相关性给出了相互矛盾的结果。然而,二元MetS定义不能连续动态地反映代谢紊乱的严重程度。本研究计算MetS评分,并探讨MetS评分与亚临床动脉粥样硬化之间的关系。方法:这项观察性横断面研究共纳入840名参与者;66.55%的参与者为男性,中位年龄为61.00岁(53.00,67.00)。2016年10月至2020年1月测量肱-踝脉波速度(baPWV)和肱血流介导的舒张(bFMD)值。采用Spearman相关和多元线性回归分析,探讨MetS评分与baPWV和bFMD的相关性。动脉硬化定义为baPWV≥1400 cm/s,内皮功能障碍定义为bFMD bbb6.0 %。采用多元logistic回归探讨MetS和MetS评分对动脉僵硬度和内皮功能障碍的影响。结果:MetS评分与baPWV显著相关(β = 73.59, 95% CI (42.70, 104.48);p < 0.001)和bFMD(β= -0.43,95% CI (-0.75, -0.10);P = 0.010)。与二元定义的MetS相比,MetS评分是动脉僵硬度更重要的预测因子(优势比,OR = 2.63, 95% CI (1.85, 3.74);p < 0.001)和内皮功能障碍(OR = 1.33, 95% CI (1.01, 1.76);P = 0.040)。白细胞计数(r = 0.32;p < 0.001)和高敏c反应蛋白(hs-CRP) (r = 0.17;p < 0.001)值与MetS评分相关。结论:MetS评分是一种临床可获得的代谢状态评估,可以识别亚临床动脉粥样硬化高风险个体。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Reviews in cardiovascular medicine
Reviews in cardiovascular medicine 医学-心血管系统
CiteScore
2.70
自引率
3.70%
发文量
377
审稿时长
1 months
期刊介绍: RCM is an international, peer-reviewed, open access journal. RCM publishes research articles, review papers and short communications on cardiovascular medicine as well as research on cardiovascular disease. We aim to provide a forum for publishing papers which explore the pathogenesis and promote the progression of cardiac and vascular diseases. We also seek to establish an interdisciplinary platform, focusing on translational issues, to facilitate the advancement of research, clinical treatment and diagnostic procedures. Heart surgery, cardiovascular imaging, risk factors and various clinical cardiac & vascular research will be considered.
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