Related factors for kidney disease and high chronic kidney disease progression risk in adult-onset type 1 diabetes mellitus patients from China: a multi-center cross-sectional study.

IF 3 3区 医学 Q1 UROLOGY & NEPHROLOGY
Renal Failure Pub Date : 2025-12-01 Epub Date: 2025-03-26 DOI:10.1080/0886022X.2025.2483389
Jun Jiang, Wenjuan Huang, Lei Lan, Xueying Zheng, Sihui Luo, Yu Ding, Jinhua Yan, Wei Ren, Kuanxiao Tang, Daizhi Yang
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Abstract

Background/aim: Concerning the related factors for kidney disease and high chronic kidney disease (CKD) progression risk, there is still a lack of study in the adult-onset type 1 diabetes mellitus (T1DM) patients from China.

Methods: Four hundred and eighty-one adult-onset T1DM patients from the Guangdong T1DM translational medicine study were included. Logistic regression analysis (Forward: LR) was utilized to identify glycemic- and nonglycemic-related factors associated with moderate albuminuria, severe albuminuria, mildly reduced estimated glomerular filtration rate (eGFR), decreased eGFR, and high CKD progression risk, and to calculate the odds ratio (OR) and 95% confidence interval (CI).

Results: High CKD progression risk was positively associated with males (OR = 3.13, 95% CI:1.20 - 8.14, p = 0.019), duration of T1DM (OR =1.13, 95% CI:1.05 - 1.21, p < 0.001), triglyceride (OR =1.52, 95% CI:1.11 - 2.08, p = 0.008), and systolic blood pressure (SBP) (OR =1.04, 95% CI:1.02 - 1.07, p = 0.001), and negatively correlated with BMI (OR = 0.80, 95% CI:0.68 - 0.95, p = 0.011). Meanwhile, moderate albuminuria, severe albuminuria, mildly reduced eGFR and decreased eGFR had different each of glycemic- and nonglycemic-related factors.

Conclusions: Hyperglycemia, hypertension, hyperuricemia, and BMI may be associated with different stages of kidney disease in adult-onset T1DM patients. Early-stage adult-onset T1DM patients with male, low BMI, prolonged diabetes duration, and comorbid hypertension and dyslipidemia should undergo a thorough evaluation of albuminuria and renal function to detect those at high CKD progression risk, who should be timely transferred to the nephrology specialty to receive professional treatment for kidney disease.

中国成人发病1型糖尿病患者肾脏疾病和慢性肾脏疾病进展高风险的相关因素:一项多中心横断面研究
背景/目的:关于肾脏疾病的相关因素和慢性肾脏病(CKD)进展的高风险,目前还缺乏对中国成年1型糖尿病(T1DM)患者的研究:方法:纳入广东省 T1DM 转化医学研究的 481 例成年 1 型糖尿病患者。采用逻辑回归分析(Forward:LR)确定与中度白蛋白尿、重度白蛋白尿、估计肾小球滤过率(eGFR)轻度降低、eGFR降低和高CKD进展风险相关的血糖相关因素和非血糖相关因素,并计算几率比(OR)和95%置信区间(CI):结果:CKD进展的高风险与男性(OR = 3.13,95% CI:1.20 - 8.14,P = 0.019)、T1DM持续时间(OR =1.13,95% CI:1.05 - 1.21,P = 0.008)、收缩压(EGFR)和肾小球滤过率(eGFR)下降(OR = 1.05,95% CI:1.05 - 1.21,P = 0.008)呈正相关。008)和收缩压(SBP)(OR =1.04,95% CI:1.02 - 1.07,P = 0.001),并与体重指数(BMI)负相关(OR = 0.80,95% CI:0.68 - 0.95,P = 0.011)。同时,中度白蛋白尿、重度白蛋白尿、eGFR轻度降低和eGFR降低与血糖和非血糖相关因素的关系各不相同:结论:高血糖、高血压、高尿酸血症和体重指数可能与成年 T1DM 患者肾脏疾病的不同阶段有关。男性、低体重指数(BMI)、糖尿病病程长、合并高血压和血脂异常的早期成年 T1DM 患者应接受白蛋白尿和肾功能的全面评估,以发现 CKD 进展风险高的患者,并及时转入肾内科接受专业的肾病治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Renal Failure
Renal Failure 医学-泌尿学与肾脏学
CiteScore
3.90
自引率
13.30%
发文量
374
审稿时长
1 months
期刊介绍: Renal Failure primarily concentrates on acute renal injury and its consequence, but also addresses advances in the fields of chronic renal failure, hypertension, and renal transplantation. Bringing together both clinical and experimental aspects of renal failure, this publication presents timely, practical information on pathology and pathophysiology of acute renal failure; nephrotoxicity of drugs and other substances; prevention, treatment, and therapy of renal failure; renal failure in association with transplantation, hypertension, and diabetes mellitus.
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