Roles of Autophagy, Mitophagy, and Mitochondria in Left Ventricular Remodeling after Myocardial Infarction.

IF 1.9 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS
Reviews in cardiovascular medicine Pub Date : 2025-03-24 eCollection Date: 2025-03-01 DOI:10.31083/RCM28195
Xin Zhang, Shuai Shao, Qiuting Li, Yi Wang, Mowei Kong, Chunxiang Zhang
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引用次数: 0

Abstract

This review examines the mechanisms of left ventricular dysfunction, focusing on the interplay between ventricular remodeling, autophagy, and mitochondrial dysfunction following myocardial infarction. Left ventricular dysfunction directly affects the heart's pumping efficiency and can lead to severe clinical outcomes, including heart failure. After myocardial infarction, the left ventricle may suffer from weakened contractility, diastolic dysfunction, and cardiac remodeling, progressing to heart failure. Thus, this article discusses the pathophysiological processes involved in ventricular remodeling, including the injury and repair of infarcted and non-infarcted myocardia, adaptive changes, and specific changes in left ventricular systolic and diastolic functions. Furthermore, the role of autophagy in maintaining cellular energy homeostasis, clearing dysfunctional mitochondria, and the key role of mitochondrial dysfunction in heart failure is addressed. Finally, this article discusses therapeutic strategies targeting mitochondrial dysfunction and enhancing mitophagy, providing clinicians and researchers with the latest insights and future research directions.

这篇综述探讨了左心室功能障碍的机制,重点是心肌梗塞后心室重塑、自噬和线粒体功能障碍之间的相互作用。左心室功能障碍直接影响心脏的泵血效率,可导致严重的临床后果,包括心力衰竭。心肌梗死后,左心室可能出现收缩力减弱、舒张功能障碍和心脏重塑,进而发展为心力衰竭。因此,本文讨论了心室重塑所涉及的病理生理过程,包括梗死和非梗死心肌的损伤和修复、适应性变化以及左心室收缩和舒张功能的具体变化。此外,文章还探讨了自噬在维持细胞能量平衡、清除功能障碍线粒体方面的作用,以及线粒体功能障碍在心力衰竭中的关键作用。最后,本文讨论了针对线粒体功能障碍和增强有丝分裂的治疗策略,为临床医生和研究人员提供了最新见解和未来研究方向。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Reviews in cardiovascular medicine
Reviews in cardiovascular medicine 医学-心血管系统
CiteScore
2.70
自引率
3.70%
发文量
377
审稿时长
1 months
期刊介绍: RCM is an international, peer-reviewed, open access journal. RCM publishes research articles, review papers and short communications on cardiovascular medicine as well as research on cardiovascular disease. We aim to provide a forum for publishing papers which explore the pathogenesis and promote the progression of cardiac and vascular diseases. We also seek to establish an interdisciplinary platform, focusing on translational issues, to facilitate the advancement of research, clinical treatment and diagnostic procedures. Heart surgery, cardiovascular imaging, risk factors and various clinical cardiac & vascular research will be considered.
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