{"title":"Prevalence and Associated Factors of Frailty in Patients with Chronic Heart Failure: A Systematic Review and Meta-Analysis.","authors":"Longren Wu, Si Liu, Meijun Zhang, Xiaoyun Xiong","doi":"10.31083/RCM26854","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Although numerous studies have investigated the prevalence of chronic heart failure (CHF) and the factors influencing frailty in patients with CHF, the findings remain inconsistent. Therefore, this review aimed to systematically evaluate the prevalence and associated frailty factors in patients with CHF to establish an evidence-based foundation for risk assessment and treatment strategies.</p><p><strong>Methods: </strong>A comprehensive search was conducted across multiple databases, including EMBASE, the Cochrane Library, PubMed, Web of Science, CINAHL, Chinese Biological Medicine (CBM), CNKI, and Wan Fang up to August 25, 2024. The objective was to identify observational studies that examined factors influencing frailty in CHF patients. The quality of the selected studies was evaluated using appropriate assessment tools, and a meta-analysis was performed to determine the relevant factors associated with frailty in this population.</p><p><strong>Results: </strong>A total of 23 articles containing 6287 patients were included. The prevalence of frailty in patients with CHF was 39% (95% confidence interval (CI): 0.33-0.45). Factors shown to be positively associated with frailty in CHF patients were older age, cerebrovascular accidents, longer hospital stay, larger left atrial diameter, higher number of comorbidities, poor New York Heart Association (NYHA) functional class, and poor sleep quality. Conversely, higher albumin, hemoglobin, and left ventricular ejection fraction (LVEF) levels were negatively associated with frailty.</p><p><strong>Conclusions: </strong>The prevalence of frailty in patients with CHF is relatively high and varies according to different assessment tools applied. Thus, establishing specific frailty assessment tools for CHF patients and providing targeted interventions based on important factors are essential for reducing the burden of frailty and improving outcomes.</p><p><strong>The prospero registration: </strong>CRD42023448771, https://www.crd.york.ac.uk/PROSPERO/view/CRD42023448771.</p>","PeriodicalId":20989,"journal":{"name":"Reviews in cardiovascular medicine","volume":"26 3","pages":"26854"},"PeriodicalIF":1.9000,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951493/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Reviews in cardiovascular medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.31083/RCM26854","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/3/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Although numerous studies have investigated the prevalence of chronic heart failure (CHF) and the factors influencing frailty in patients with CHF, the findings remain inconsistent. Therefore, this review aimed to systematically evaluate the prevalence and associated frailty factors in patients with CHF to establish an evidence-based foundation for risk assessment and treatment strategies.
Methods: A comprehensive search was conducted across multiple databases, including EMBASE, the Cochrane Library, PubMed, Web of Science, CINAHL, Chinese Biological Medicine (CBM), CNKI, and Wan Fang up to August 25, 2024. The objective was to identify observational studies that examined factors influencing frailty in CHF patients. The quality of the selected studies was evaluated using appropriate assessment tools, and a meta-analysis was performed to determine the relevant factors associated with frailty in this population.
Results: A total of 23 articles containing 6287 patients were included. The prevalence of frailty in patients with CHF was 39% (95% confidence interval (CI): 0.33-0.45). Factors shown to be positively associated with frailty in CHF patients were older age, cerebrovascular accidents, longer hospital stay, larger left atrial diameter, higher number of comorbidities, poor New York Heart Association (NYHA) functional class, and poor sleep quality. Conversely, higher albumin, hemoglobin, and left ventricular ejection fraction (LVEF) levels were negatively associated with frailty.
Conclusions: The prevalence of frailty in patients with CHF is relatively high and varies according to different assessment tools applied. Thus, establishing specific frailty assessment tools for CHF patients and providing targeted interventions based on important factors are essential for reducing the burden of frailty and improving outcomes.
The prospero registration: CRD42023448771, https://www.crd.york.ac.uk/PROSPERO/view/CRD42023448771.
背景：尽管许多研究调查了慢性心力衰竭（CHF）的患病率和影响CHF患者虚弱的因素，但研究结果仍然不一致。因此，本综述旨在系统评估CHF患者的患病率及相关脆弱因素，为风险评估和治疗策略建立循证基础。方法：截至2024年8月25日，在EMBASE、Cochrane Library、PubMed、Web of Science、CINAHL、Chinese Biological Medicine （CBM）、CNKI、万方等多个数据库进行综合检索。目的是确定观察性研究，检查影响心力衰竭患者虚弱的因素。使用适当的评估工具对所选研究的质量进行评估，并进行荟萃分析以确定与该人群虚弱相关的相关因素。结果：共纳入23篇文献，6287例患者。心力衰竭患者的虚弱患病率为39%（95%可信区间（CI）： 0.33-0.45）。与心力衰竭患者虚弱正相关的因素有：年龄较大、脑血管意外、住院时间较长、左房内径较大、合合症较多、纽约心脏协会（NYHA）功能分级差、睡眠质量差。相反，较高的白蛋白、血红蛋白和左心室射血分数（LVEF）水平与虚弱呈负相关。结论：心力衰竭患者的虚弱患病率较高，且根据不同的评估工具而有所不同。因此，为CHF患者建立特定的虚弱评估工具，并根据重要因素提供有针对性的干预措施，对于减轻虚弱负担和改善预后至关重要。普洛斯彼罗注册：CRD42023448771， https://www.crd.york.ac.uk/PROSPERO/view/CRD42023448771。
期刊介绍：
RCM is an international, peer-reviewed, open access journal. RCM publishes research articles, review papers and short communications on cardiovascular medicine as well as research on cardiovascular disease. We aim to provide a forum for publishing papers which explore the pathogenesis and promote the progression of cardiac and vascular diseases. We also seek to establish an interdisciplinary platform, focusing on translational issues, to facilitate the advancement of research, clinical treatment and diagnostic procedures. Heart surgery, cardiovascular imaging, risk factors and various clinical cardiac & vascular research will be considered.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
