Advances and Prospects in Using Induced Pluripotent Stem Cells for 3D Bioprinting in Cardiac Tissue Engineering.

IF 1.9 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS
Reviews in cardiovascular medicine Pub Date : 2025-03-19 eCollection Date: 2025-03-01 DOI:10.31083/RCM26697
Baoluo Du, Ziqiang Dai, Huan Wang, Zhipeng Ren, Dianyuan Li
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Abstract

Background: Cardiovascular diseases remain one of the leading causes of death worldwide. Given the limited self-repair capacity of cardiac tissue, cardiac tissue engineering (CTE) aims to develop strategies and materials for repairing or replacing damaged cardiac tissue by combining biology, medicine, and engineering. Indeed, CTE has made significant strides since the discovery of induced pluripotent stem cells (iPSCs) in 2006, including creating cardiac patches, organoids, and chip models derived from iPSCs, thus offering new strategies for treating cardiac diseases.

Methods: A systematic search for relevant literature published between 2003 and 2024 was conducted in the PubMed and Web of Science databases using "Cardiac Tissue Engineering", "3D Bioprinting", "Scaffold in Tissue Engineering", "Induced Pluripotent Stem Cells", and "iPSCs" as keywords.

Results: This systematic search using the abovementioned keywords identified relevant articles for inclusion in this review. The resulting literature indicated that CTE can offer innovative solutions for treating cardiac diseases when integrated with three-dimensional (3D) bioprinting and iPSC technology.

Conclusions: Despite notable advances in the field of CTE, multiple challenges remain relating to 3D-bioprinted cardiac tissues. These include maintaining long-term cell viability, achieving precise cell distribution, tissue vascularization, material selection, and cost-effectiveness. Therefore, further research is needed to optimize printing techniques, develop more advanced bio-inks, explore larger-scale tissue constructs, and ensure the biosafety and functional fidelity of engineered cardiac tissues. Subsequently, future research efforts should focus on these areas to facilitate the clinical translation of CTE. Moreover, additional long-term animal models and preclinical studies should be conducted to ensure the biosafety and functionality of engineered cardiac tissues, thereby creating novel possibilities for treating patients with heart diseases.

背景:心血管疾病仍然是全球死亡的主要原因之一。鉴于心脏组织的自我修复能力有限,心脏组织工程(CTE)旨在结合生物学、医学和工程学,开发修复或替代受损心脏组织的策略和材料。事实上,自 2006 年发现诱导多能干细胞(iPSCs)以来,CTE 已取得了长足的进步,包括创建由 iPSCs 衍生的心脏补片、器官组织和芯片模型,从而为治疗心脏疾病提供了新的策略:以 "心脏组织工程"、"3D 生物打印"、"组织工程中的支架"、"诱导多能干细胞 "和 "iPSCs "为关键词,在 PubMed 和 Web of Science 数据库中对 2003 年至 2024 年间发表的相关文献进行了系统检索:使用上述关键词进行的系统性搜索确定了相关文章,并将其纳入本综述。结果表明,CTE 与三维(3D)生物打印和 iPSC 技术相结合,可为治疗心脏疾病提供创新解决方案:结论:尽管 CTE 领域取得了显著进展,但三维生物打印心脏组织仍面临多重挑战。这些挑战包括保持细胞长期存活、实现细胞精确分布、组织血管化、材料选择和成本效益。因此,需要进一步研究优化打印技术,开发更先进的生物墨水,探索更大规模的组织构建,并确保工程心脏组织的生物安全性和功能保真度。因此,未来的研究工作应重点关注这些领域,以促进 CTE 的临床转化。此外,还应开展更多的长期动物模型和临床前研究,以确保工程心脏组织的生物安全性和功能性,从而为治疗心脏病患者创造新的可能性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Reviews in cardiovascular medicine
Reviews in cardiovascular medicine 医学-心血管系统
CiteScore
2.70
自引率
3.70%
发文量
377
审稿时长
1 months
期刊介绍: RCM is an international, peer-reviewed, open access journal. RCM publishes research articles, review papers and short communications on cardiovascular medicine as well as research on cardiovascular disease. We aim to provide a forum for publishing papers which explore the pathogenesis and promote the progression of cardiac and vascular diseases. We also seek to establish an interdisciplinary platform, focusing on translational issues, to facilitate the advancement of research, clinical treatment and diagnostic procedures. Heart surgery, cardiovascular imaging, risk factors and various clinical cardiac & vascular research will be considered.
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