The role of osteopontin in chronic kidney disease-mineral bone disorder.

IF 2.2 3区医学 Q3 PERIPHERAL VASCULAR DISEASE

Current Opinion in Nephrology and Hypertension Pub Date : 2025-07-01 Epub Date: 2025-04-01 DOI:10.1097/MNH.0000000000001074

Eduardo J Duque, Cecilia Giachelli, Rosa M A Moysés

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引用次数: 0

Abstract

Purpose of review: Chronic kidney disease-mineral bone disorder (CKD-MBD) is associated with several adverse outcomes, including bone fragility and sarcopenia. Identification of new agents mitigating systemic damage related to uremia is critical and needed to unveil pathways implicated in CKD-MBD.

Recent findings: Osteopontin (OPN) is involved in different physiological and pathological processes and works as a bridge connecting several systems. It may serve as a biomarker for many diseases, including human cancers, neurodegenerative disorders and autoimmune diseases. OPN has been implicated in disturbances of bone mineralization and remodeling, and has an interplay with parathyroid hormone and FGF23 in experimental models. In patients with CKD and severe hyperparathyroidism, OPN expression in muscle tissue has been linked to worse functionality and local inflammation, which is partially reverted after parathyroidectomy.

Summary: Future studies could confirm the role of OPN as a biomarker in nephrology. Greater understanding of its role in CKD-MBD will help us define a better therapeutic strategy in patients with CKD.

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骨桥蛋白在慢性肾病-矿物质骨紊乱中的作用。

综述目的：慢性肾脏疾病-矿物质骨障碍（CKD-MBD）与几种不良后果相关，包括骨脆性和肌肉减少症。确定减轻尿毒症相关的系统性损害的新药物是至关重要的，并且需要揭示CKD-MBD的相关途径。近期研究发现：骨桥蛋白（Osteopontin， OPN）参与不同的生理和病理过程，是连接多个系统的桥梁。它可以作为许多疾病的生物标志物，包括人类癌症、神经退行性疾病和自身免疫性疾病。在实验模型中，OPN与骨矿化和骨重塑紊乱有关，并与甲状旁腺激素和FGF23相互作用。在CKD和严重甲状旁腺功能亢进患者中，肌肉组织中的OPN表达与功能恶化和局部炎症有关，甲状旁腺切除术后部分恢复。摘要：未来的研究可以证实OPN作为肾脏病学生物标志物的作用。更深入地了解其在CKD- mbd中的作用将有助于我们为CKD患者制定更好的治疗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Nephrology and Hypertension 医学-泌尿学与肾脏学

CiteScore

5.70

自引率

6.20%

发文量

132

审稿时长

6-12 weeks

期刊介绍： A reader-friendly resource, Current Opinion in Nephrology and Hypertension provides an up-to-date account of the most important advances in the field of nephrology and hypertension. Each issue contains either two or three sections delivering a diverse and comprehensive coverage of all the key issues, including pathophysiology of hypertension, circulation and hemodynamics, and clinical nephrology. Current Opinion in Nephrology and Hypertension is an indispensable journal for the busy clinician, researcher or student.