Association of metformin administration with the serum levels of zinc and homocysteine in patients with type 2 diabetes: a cross-sectional study.

IF 1.3 Q4 ENDOCRINOLOGY & METABOLISM

Diabetology International Pub Date : 2025-02-08 eCollection Date: 2025-04-01 DOI:10.1007/s13340-025-00798-x

Sadako Matsui, Chika Hiraishi, Ryo Sato, Takai Kojima, Keiichiro Matoba, Kei Fujimoto, Hiroshi Yoshida

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Abstract

Background: Metformin treatment has a risk factor of reduced serum concentrations of vitamin B12 and zinc, indicating its association with homocysteine metabolism. However, this association remains to be clarified in patients with type 2 diabetes (T2DM) accompanied by kidney dysfunction.

Methods: This cross-sectional study was conducted in 149 patients with T2DM (96 men, 53 women), including diabetic kidney disease. Serum concentrations of homocysteine, as well as vitamin B12, folic acid, and zinc, were measured in outpatient T2DM patients. The study subjects were divided into two groups: patients with and without metformin administration (Met [ +], n = 62; Met [ -], n = 87). To explore the effect of kidney function, we also analyzed the data after dividing all the patients according to kidney function (chronic kidney disease [CKD] group, n = 66; non-CKD group, n = 83).

Results: The Met ( +) group exhibited significantly higher serum zinc levels and lower serum homocysteine levels than the Met ( -) group. In the non-CKD group, metformin administration was positively associated with serum zinc levels, as demonstrated by multiple linear regression analysis adjusted for confounding factors (β = 0.287, p = 0.021). However, no significant association between metformin administration and serum zinc levels was observed in the CKD group. Moreover, there were no associations between serum homocysteine levels and metformin administration.

Conclusions: The relationship between metformin treatment and serum zinc levels differed based on the presence or absence of CKD in patients with T2DM.

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二甲双胍与2型糖尿病患者血清锌和同型半胱氨酸水平的关系：一项横断面研究

背景：二甲双胍治疗有降低血清维生素B12和锌浓度的危险因素，表明其与同型半胱氨酸代谢有关。然而，这种关联在伴有肾功能障碍的2型糖尿病（T2DM）患者中仍有待明确。方法：本横断面研究纳入149例T2DM患者（男性96例，女性53例），包括糖尿病肾病。在门诊T2DM患者中测定血清同型半胱氨酸、维生素B12、叶酸和锌的浓度。研究对象分为两组：服用和未服用二甲双胍的患者(Met [+], n = 62；Met [-], n = 87)。为探讨对肾功能的影响，我们还对所有患者按肾功能进行分组后的数据进行分析(慢性肾病[CKD]组，n = 66；非ckd组，n = 83)。结果：Met（+）组血清锌水平显著高于Met（-）组，血清同型半胱氨酸水平显著低于Met（-）组。在非ckd组中，经校正混杂因素的多元线性回归分析证实，二甲双胍给药与血清锌水平呈正相关（β = 0.287, p = 0.021）。然而，在CKD组中，没有观察到二甲双胍给药与血清锌水平之间的显著关联。此外，血清同型半胱氨酸水平与二甲双胍给药之间没有关联。结论：二甲双胍治疗与血清锌水平的关系因T2DM患者是否存在CKD而异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetology International ENDOCRINOLOGY & METABOLISM-

CiteScore

3.90

自引率

4.50%

发文量

期刊介绍： Diabetology International, the official journal of the Japan Diabetes Society, publishes original research articles about experimental research and clinical studies in diabetes and related areas. The journal also presents editorials, reviews, commentaries, reports of expert committees, and case reports on any aspect of diabetes. Diabetology International welcomes submissions from researchers, clinicians, and health professionals throughout the world who are interested in research, treatment, and care of patients with diabetes. All manuscripts are peer-reviewed to assure that high-quality information in the field of diabetes is made available to readers. Manuscripts are reviewed with due respect for the author''s confidentiality. At the same time, reviewers also have rights to confidentiality, which are respected by the editors. The journal follows a single-blind review procedure, where the reviewers are aware of the names and affiliations of the authors, but the reviewer reports provided to authors are anonymous. Single-blind peer review is the traditional model of peer review that many reviewers are comfortable with, and it facilitates a dispassionate critique of a manuscript.