Association of early onset gestational diabetes mellitus with postpartum glucose intolerance.

IF 1.3 Q4 ENDOCRINOLOGY & METABOLISM

Diabetology International Pub Date : 2025-02-22 eCollection Date: 2025-04-01 DOI:10.1007/s13340-025-00807-z

Akihito Morita, Ayuko Tanaka, Daisuke Higeta, Tatsuya Sato, Eijiro Yamada, Akira Iwase

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引用次数: 0

Abstract

Background: This study aimed to investigate the association between postpartum glucose intolerance and the timing of gestational diabetes mellitus (GDM) diagnosis according to criteria from the International Association of Diabetes and Pregnancy Study Groups (IADPSG).

Methods: A single-center retrospective case-control study involving patients diagnosed with GDM according to IADPSG criteria was conducted. Patients underwent a postpartum 75 g oral glucose tolerance test (OGTT) and were divided into 2 groups: normal (control) and abnormal glucose tolerance (AGT). Gestational age at GDM diagnosis and the maternal and neonatal outcomes were compared between the groups.

Results: Data from 177 controls and 102 patients diagnosed with AGT were analyzed. The AGT group exhibited a higher pre-pregnancy body mass index, family history of diabetes, glycated hemoglobin level at the initial visit, and total daily insulin dose, but a lower rate of GDM diagnosis at 24-32 weeks' gestation. GDM diagnosed before 24 weeks' gestation was independently associated with AGT (adjusted odds ratio 2.18 [95% confidence interval 1.28-3.73]; p < 0.01]). Additionally, a higher proportion of patients diagnosed with GDM before 24 weeks' gestation had a lower disposition index (27.1% versus 14.8%; p = 0.01).

Conclusions: Patients diagnosed with GDM at < 24 weeks' gestation were at higher risk for postpartum glucose intolerance than those diagnosed at 24-32 weeks. The lower disposition index in patients early diagnosed highlights the need for tailored postpartum follow-up to address their specific risks.

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来源期刊

Diabetology International ENDOCRINOLOGY & METABOLISM-

CiteScore

3.90

自引率

4.50%

发文量

期刊介绍： Diabetology International, the official journal of the Japan Diabetes Society, publishes original research articles about experimental research and clinical studies in diabetes and related areas. The journal also presents editorials, reviews, commentaries, reports of expert committees, and case reports on any aspect of diabetes. Diabetology International welcomes submissions from researchers, clinicians, and health professionals throughout the world who are interested in research, treatment, and care of patients with diabetes. All manuscripts are peer-reviewed to assure that high-quality information in the field of diabetes is made available to readers. Manuscripts are reviewed with due respect for the author''s confidentiality. At the same time, reviewers also have rights to confidentiality, which are respected by the editors. The journal follows a single-blind review procedure, where the reviewers are aware of the names and affiliations of the authors, but the reviewer reports provided to authors are anonymous. Single-blind peer review is the traditional model of peer review that many reviewers are comfortable with, and it facilitates a dispassionate critique of a manuscript.