Functions and mechanisms of non-histone post-translational modifications in cancer progression.

IF 6.1 2区生物学 Q1 CELL BIOLOGY

Cell Death Discovery Pub Date : 2025-03-31 DOI:10.1038/s41420-025-02410-2

Zongyang Li, Tao Zhu, Yushu Wu, Yongbo Yu, Yunjiang Zang, Lebo Yu, Zhilei Zhang

引用次数: 0

Abstract

Protein post-translational modifications (PTMs) refer to covalent and enzymatic alterations to folded or nascent proteins during or after protein biosynthesis to alter the properties and functions of proteins. PTMs are modified in a variety of types and affect almost all aspects of cell biology. PTMs have been reported to be involved in cancer progression by influencing multiple signaling pathways. The mechanism of action of histone PTMs in cancer has been extensively studied. Notably, evidence is mounting that PTMs of non-histone proteins also play a vital role in cancer progression. In this review, we provide a systematic description of main non-histone PTMs associated with cancer progression, including acetylation, lactylation, methylation, ubiquitination, phosphorylation, and SUMOylation, based on recent studies.

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非组蛋白翻译后修饰在癌症进展中的功能和机制。

蛋白质翻译后修饰（PTMs）是指在蛋白质生物合成过程中或之后对折叠或新生蛋白质进行的共价和酶促改变，以改变蛋白质的性质和功能。PTMs被修改为多种类型，并影响细胞生物学的几乎所有方面。据报道，ptm通过影响多种信号通路参与癌症进展。组蛋白PTMs在癌症中的作用机制已被广泛研究。值得注意的是，越来越多的证据表明，非组蛋白的ptm在癌症进展中也起着至关重要的作用。在这篇综述中，我们根据最近的研究，系统地描述了与癌症进展相关的主要非组蛋白PTMs，包括乙酰化、乳酸化、甲基化、泛素化、磷酸化和sumo化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Death Discovery Biochemistry, Genetics and Molecular Biology-Cell Biology

CiteScore

8.30

自引率

1.40%

发文量

468

审稿时长

9 weeks

期刊介绍： Cell Death Discovery is a multidisciplinary, international, online-only, open access journal, dedicated to publishing research at the intersection of medicine with biochemistry, pharmacology, immunology, cell biology and cell death, provided it is scientifically sound. The unrestricted access to research findings in Cell Death Discovery will foster a dynamic and highly productive dialogue between basic scientists and clinicians, as well as researchers in industry with a focus on cancer, neurobiology and inflammation research. As an official journal of the Cell Death Differentiation Association (ADMC), Cell Death Discovery will build upon the success of Cell Death & Differentiation and Cell Death & Disease in publishing important peer-reviewed original research, timely reviews and editorial commentary. Cell Death Discovery is committed to increasing the reproducibility of research. To this end, in conjunction with its sister journals Cell Death & Differentiation and Cell Death & Disease, Cell Death Discovery provides a unique forum for scientists as well as clinicians and members of the pharmaceutical and biotechnical industry. It is committed to the rapid publication of high quality original papers that relate to these subjects, together with topical, usually solicited, reviews, editorial correspondence and occasional commentaries on controversial and scientifically informative issues.