Platelet-Derived Growth Factor as Biomarker of Clinical Outcome for Autologous Platelet Concentrate Therapy in Grade I Knee Osteoarthritis.

IF 5.3 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Biologics : Targets & Therapy Pub Date : 2025-03-25 eCollection Date: 2025-01-01 DOI:10.2147/BTT.S500522

Michele Francesco Di Tolla, Serena Romano, Pietro Vassetti, Domenico Perugini, Immacolata Filoso, Serena Cabaro, Giusy Ferraro, Francesco Oriente, Giuseppe Perruolo, Flora Arvonio, Vittoria D'Esposito, Pietro Formisano

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Abstract

Introduction: Autologous platelet concentrates (APC) are widely used in the infiltrative treatment of knee osteoarthritis (OA) to enhance tissue healing and relieve pain. Aim of this study was to identify predictive biomarkers for clinical outcomes in patients with grade I knee OA.

Methods: A panel of growth factors (GFs) and cytokines was determined in peripheral blood (PB) and APC. The Numeric Pain Rating Scale (NPRS) was used as a clinical readout before and after the APC infiltration.

Results: A lower white blood cell (WBC) count and higher Monocyte-chemoattractant Protein-1 levels in PB were associated with APC-induced pain relief. Platelet-derived Growth Factor (PDGF) levels in APC were significantly higher in OA patients displaying a larger NPRS reduction, independent of platelet count. Finally, the simultaneous determination of PDGF, Vascular Endothelial Growth Factor, and Macrophage Inflammatory Protein-1α in APC discriminated OA patients with very poor or no response.

Conclusion: Platelet-released GFs rather than platelet counts may predict clinical outcomes in grade 1 knee OA.

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血小板衍生生长因子作为自体浓缩血小板治疗I级膝骨关节炎临床结果的生物标志物

自体血小板浓缩物（APC）广泛应用于膝关节骨性关节炎（OA）的浸润治疗，以促进组织愈合和缓解疼痛。本研究的目的是确定I级膝关节OA患者临床结果的预测性生物标志物。方法：测定外周血（PB）和APC中生长因子（GFs）和细胞因子（cytokines）的含量。数值疼痛评定量表（NPRS）作为APC浸润前后的临床读数。结果：低白细胞（WBC）计数和高单核细胞化学引诱蛋白-1水平与apc诱导的疼痛缓解有关。OA患者APC中血小板衍生生长因子（PDGF）水平显著升高，NPRS降低幅度更大，与血小板计数无关。最后，同时检测APC中PDGF、血管内皮生长因子和巨噬细胞炎症蛋白-1α，以区分极差或无反应的OA患者。结论：血小板释放的GFs比血小板计数更能预测1级膝关节OA的临床结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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