Polylactic Acid Membrane for the Treatment of Pediatric Burn Injuries: An Adoptable Practice to Improve Burn Management.

IF 1.4 4区 医学 Q3 SURGERY
Brielle E Raine, Cody C Fowler, Antoinette Nguyen, Piper Schneider, Kiernan J Gunn, Rishika Chikoti, Derek E Bell
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引用次数: 0

Abstract

Background: Polylactic acid membrane (PLAM) is a one-time application alloplastic skin substitute that has been utilized as an adjunct for pediatric burns for a multitude of indications. Literature has established its utility in mixed superficial and deep dermal burns, with advantages related to decreased need for procedures requiring general anesthesia and decreased overall healthcare cost (Eur Burn J 2021;3(1):1-9). Additionally, its application has been comparable in wound healing outcomes to established standard of care practices (Burns 2023;49(7):1585-1591, Wound Repair Regen 2006;14(3):321-4). Our study analyzes the impact of integrating PLAM into pediatric burn management at a single burn center. We hypothesize that the integration of PLAM into our practice would result in improved outcomes related to wound care needs, surgical efficiency, hospital length of stay, and overall wound healing.

Methods: We conducted a retrospective study of all pediatric (<18 years of age) patients with second- and third-degree burns treated at a single American Burn Association (ABA)-verified pediatric burn center from December 2019 to April 2024. All burn etiologies were included, and isolated first-degree burns were excluded. Our retrospective cohort was separated into two distinct treatment periods (pretherapy Era 1 and posttherapy Era 2) based on time before and after the introduction of PLAM at our institution (March 1, 2022). Data on patient demographics, burn characteristics, hospitalization treatments, operative details, surgical outcomes, and time to wound healing were analyzed.

Results: A total of 331 pediatric patients met the inclusion criteria. A total of 155 patients were included in our pretherapy Era 1 and 176 patients in our posttherapy Era 2. The average age was 5.6 years old, and the majority of patients were male (62.2%) and White (55.0%). Baseline characteristics between our two cohorts were comparable across age, gender, race, ethnicity, BMI, mechanism of burn, and total body surface area (TBSA) burned. The need for sedated burn care significantly decreased after the introduction of PLAM (72.9% vs 59.4%, P = 0.010), and the average number of days of sedation decreased as well (3.7 vs 2.1 days, P < 0.001). Forty-one percent of all patients underwent surgical intervention for their burns with a significant increase in the number of patients receiving surgery in the posttherapy era (32.9% vs 48.3%, P < 0.001). Additionally, time from burn to surgery shortened in Era 2 (9.1 vs 7.2 days, P < 0.001). There was a statistically significant reduction in median procedure time in Era 2 (26 vs 13 minutes, P < 0.001). Finally, we observed significant reductions in median length of hospital stay (5 vs 4 days, P = 0.004), postoperative length of stay (1 vs 0 days, P = 0.017), the need for sedated postoperative dressing changes (54.9% vs 18.8%, P < 0.001), and need for home nursing visits (51.0% vs 17.1%, P < 0.001) in Era 2.

Conclusions: The integration of PLAMs into pediatric burn management provides significant benefits. Our study highlights the decreased need for sedated burn care, improved operative efficiency, decreased time to surgical intervention, shortened hospital stays, the decreasing demand for home nursing visits, and minimized need for additional surgeries, with healing outcomes comparable to current standard of care practices. These findings suggest potential cost savings for healthcare systems, improved healthcare efficiency, and increased patient satisfaction.

聚乳酸膜治疗儿童烧伤:改善烧伤管理的一种可采用的做法。
背景:聚乳酸膜(PLAM)是一种一次性应用的同种异体皮肤替代品,已被用作儿科烧伤的辅助治疗。文献已经证实了它在浅层和深层混合皮肤烧伤中的应用,其优势在于减少了需要全身麻醉的手术,降低了总体医疗成本(Eur Burn J 2021;3(1):1-9)。此外,它的应用在伤口愈合结果方面与既定的标准护理实践相当(烧伤2023;49(7):1585-1591;伤口修复Regen 2006;14(3):321-4)。我们的研究分析了在单一烧伤中心将PLAM纳入儿科烧伤管理的影响。我们假设将PLAM整合到我们的实践中可以改善与伤口护理需求、手术效率、住院时间和整体伤口愈合相关的结果。方法:我们对所有儿童进行回顾性研究(结果:共有331例儿童患者符合纳入标准。共有155名患者被纳入我们的治疗前第1期,176名患者被纳入我们的治疗后第2期。平均年龄5.6岁,以男性(62.2%)和白人(55.0%)居多。我们两个队列的基线特征在年龄、性别、种族、民族、BMI、烧伤机制和烧伤总体表面积(TBSA)方面具有可比性。引入PLAM后,镇静烧伤护理的需求显著减少(72.9% vs 59.4%, P = 0.010),镇静平均天数也减少(3.7 vs 2.1天,P < 0.001)。41%的患者接受了手术治疗,治疗后接受手术治疗的患者数量显著增加(32.9%比48.3%,P < 0.001)。此外,第2期从烧伤到手术的时间缩短(9.1天vs 7.2天,P < 0.001)。第2期中位手术时间减少有统计学意义(26 vs 13分钟,P < 0.001)。最后,我们观察到,在第2期,中位住院时间(5天vs 4天,P = 0.004)、术后住院时间(1天vs 0天,P = 0.017)、镇静术后换药的需要(54.9% vs 18.8%, P < 0.001)和家庭护理的需要(51.0% vs 17.1%, P < 0.001)显著减少。结论:将PLAMs整合到小儿烧伤管理中具有显著的益处。我们的研究强调了镇静烧伤护理需求的减少,手术效率的提高,手术干预时间的缩短,住院时间的缩短,家庭护理就诊需求的减少,以及对额外手术的需求的最小化,治疗结果与目前的标准护理实践相当。这些发现提示了医疗保健系统的潜在成本节约、医疗保健效率的提高和患者满意度的提高。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
2.70
自引率
13.30%
发文量
584
审稿时长
6 months
期刊介绍: The only independent journal devoted to general plastic and reconstructive surgery, Annals of Plastic Surgery serves as a forum for current scientific and clinical advances in the field and a sounding board for ideas and perspectives on its future. The journal publishes peer-reviewed original articles, brief communications, case reports, and notes in all areas of interest to the practicing plastic surgeon. There are also historical and current reviews, descriptions of surgical technique, and lively editorials and letters to the editor.
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