Modulation of Host Immunity by Microbiome-Derived Indole-3-Propionic Acid and Other Bacterial Metabolites

IF 4.5 3区 医学 Q2 IMMUNOLOGY
Burkhard Schütz, Felix F. Krause, R. Verena Taudte, Mario M. Zaiss, Maik Luu, Alexander Visekruna
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引用次数: 0

Abstract

In recent years, we have witnessed a rapidly growing interest in the intricate communications between intestinal microorganisms and the host immune system. Research on the human microbiome is evolving from merely descriptive and correlative studies to a deeper mechanistic understanding of the bidirectional interactions between gut microbiota and the mucosal immune system. Despite numerous challenges, it has become increasingly evident that an imbalance in gut microbiota composition, known as dysbiosis, is associated with the development and progression of various metabolic, immune, cancer, and neurodegenerative disorders. A growing body of evidence highlights the importance of small molecules produced by intestinal commensal bacteria, collectively referred to as gut microbial metabolites. These metabolites serve as crucial diffusible messengers, translating the microbial language to host cells. This review aims to explore the complex and not yet fully understood molecular mechanisms through which microbiota-derived metabolites influence the activity of the immune cells and shape immune reactions in the gut and other organs. Specifically, we will discuss recent research that reveals the close relationship between microbial indole-3-propionic acid (IPA) and mucosal immunity. Furthermore, we will emphasize the beneficial effects of IPA on intestinal inflammation and discuss its potential clinical implications.

Abstract Image

微生物衍生的吲哚-3-丙酸和其他细菌代谢物对宿主免疫的调节
近年来,我们对肠道微生物与宿主免疫系统之间复杂的通讯产生了迅速增长的兴趣。对人类微生物组的研究正在从仅仅描述性和相关性的研究发展到对肠道微生物群与粘膜免疫系统之间双向相互作用的更深入的机制理解。尽管面临诸多挑战,但越来越明显的是,肠道微生物群组成的不平衡,即生态失调,与各种代谢、免疫、癌症和神经退行性疾病的发生和进展有关。越来越多的证据强调了肠道共生细菌产生的小分子的重要性,这些小分子统称为肠道微生物代谢物。这些代谢物作为关键的扩散信使,将微生物语言翻译给宿主细胞。本文旨在探讨微生物衍生代谢物影响肠道和其他器官中免疫细胞活性和形成免疫反应的复杂而尚未完全理解的分子机制。具体来说,我们将讨论揭示微生物吲哚-3-丙酸(IPA)与粘膜免疫之间密切关系的最新研究。此外,我们将强调IPA对肠道炎症的有益作用,并讨论其潜在的临床意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
8.30
自引率
3.70%
发文量
224
审稿时长
2 months
期刊介绍: The European Journal of Immunology (EJI) is an official journal of EFIS. Established in 1971, EJI continues to serve the needs of the global immunology community covering basic, translational and clinical research, ranging from adaptive and innate immunity through to vaccines and immunotherapy, cancer, autoimmunity, allergy and more. Mechanistic insights and thought-provoking immunological findings are of interest, as are studies using the latest omics technologies. We offer fast track review for competitive situations, including recently scooped papers, format free submission, transparent and fair peer review and more as detailed in our policies.
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