Syntheses, characterization and crystal structures of cobalt(II/III) and copper(II) complexes derived from 5-bromo-2-(isopropyliminomethyl)phenolwith antibacterial activity

IF 2.4 3区化学 Q2 CHEMISTRY, INORGANIC & NUCLEAR

Polyhedron Pub Date : 2025-03-29 DOI:10.1016/j.poly.2025.117520

Chengbin Sun, Xiuhua Wen, Wei Kan, Bing Zhao

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Abstract

A bidentate Schiff base ligand 5-bromo-2-(isopropyliminomethyl)phenol(HL) was prepared and characterized by IR and ¹H NMR spectra. Reaction of the Schiff base as ligand with cobalt nitrate and copper bromide, respectively, in the presence of sodium azide or sodium dicyanamide, afforded three new cobalt(II/III) and copper(II) complexes [Co^II(Co^IIIL₂(N₃)₂)₂] (1), [CuL₂] (2) and [Cu₂L₂(dca)₂]_n (3) (dca = dicyanoamide). The complexes were characterized by IR spectra, as well as single crystal X-ray diffraction. Powder X-ray diffraction was performed to verify the purity of the complexes. The Schiff base ligand coordinates to the metal atoms through its phenolate O and imino N atoms. The biological assay indicates that the complexes have effective activities on the bacterial strains B. subtilis, S. aureus and E. coli.

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具有抗菌活性的5-溴-2-（异丙基甲基）苯酚衍生钴（II/III）和铜（II）配合物的合成、表征和晶体结构

制备了一种双齿希夫碱配体5-溴-2-（异丙基甲基）苯酚（HL），并用IR和1H NMR对其进行了表征。在叠氮化钠或双氰酰胺钠存在下，席夫碱作为配体分别与硝酸钴和溴化铜反应，得到三个新的钴（II/III）和铜（II）配合物[CoII(CoIIIL2(N3)2)2] (1), [CuL2](2)和[Cu2L2(dca)2]n (3) （dca =双氰酰胺）。用红外光谱和x射线单晶衍射对配合物进行了表征。粉末x射线衍射验证了配合物的纯度。希夫碱配体通过其酚O和亚氨基N原子与金属原子进行配位。生物实验表明，该配合物对枯草芽孢杆菌、金黄色葡萄球菌和大肠杆菌均有较好的抑制作用。

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来源期刊

Polyhedron 化学-晶体学

CiteScore

4.90

自引率

7.70%

发文量

515

审稿时长

2 months

期刊介绍： Polyhedron publishes original, fundamental, experimental and theoretical work of the highest quality in all the major areas of inorganic chemistry. This includes synthetic chemistry, coordination chemistry, organometallic chemistry, bioinorganic chemistry, and solid-state and materials chemistry. Papers should be significant pieces of work, and all new compounds must be appropriately characterized. The inclusion of single-crystal X-ray structural data is strongly encouraged, but papers reporting only the X-ray structure determination of a single compound will usually not be considered. Papers on solid-state or materials chemistry will be expected to have a significant molecular chemistry component (such as the synthesis and characterization of the molecular precursors and/or a systematic study of the use of different precursors or reaction conditions) or demonstrate a cutting-edge application (for example inorganic materials for energy applications). Papers dealing only with stability constants are not considered.