Organometallic Reagent-Free Iron-Catalyzed C–Cl Bond Activation of Aryl Chlorines

IF 4.9 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-04-01 DOI:10.1021/acs.orglett.5c00877

Leifeng Yuan, Wenli Zhuang, Zemin Wang, Xiaowei Li, Cong Shi, Xiangqian Li, Dayong Shi

引用次数: 0

Abstract

The formation of C–C and C–S bonds is fundamentally important for the production of pharmaceuticals, biologically active molecules, and organic natural products. Herein, we report an unprecedented iron-catalyzed process for C–C and C–S bond coupling to achieve the 1,2-arylthiolation of alkenes. This process proceeds efficiently without the use of organometallic reagents and features readily available starting materials, a broad substrate scope, and simple reaction conditions

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.