Research progress on the role and molecular mechanism of PRDX4 in malignant tumors.

Abstract

Peroxiredoxin IV (PRDX4) is an important member of the Peroxiredoxin (PRDX) family. Studies in recent years have shown that PRDX4, as an antioxidant enzyme, plays a crucial role in processes such as protein folding, DNA damage, inflammatory responses, and tumorigenesis. At the molecular mechanism level, PRDX4 can act as a key regulatory factor in redox signaling pathways and regulate the levels of reactive oxygen species (ROS) within cells through oxidative defense mechanisms. Although there is evidence supporting that PRDX4 may become a new target for the treatment of certain malignant tumors, its biological functions and related molecular mechanisms in different types of malignant tumors are still controversial and not fully elucidated, thus requiring further in - depth exploration. This review aims to summarize the roles of PRDX4 in malignant tumors and its potential molecular mechanisms in recent years, with a view to providing new perspectives for future research.