The Application Value of Intraoperative Neurophysiological Monitoring in Cervical Spinal Canal Stenosis Decompression Surgery.

IF 4.9 1区 医学 Q1 CLINICAL NEUROLOGY
Yongjie Zhang, Jialiang Li, Yang Yuan, Yuchen Wang, Dageng Huang, Huaguang Qi
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引用次数: 0

Abstract

Background context: Although intraoperative neurophysiological monitoring (IONM) has been widely recognized and used in spine surgery, its characteristics vary for different types of spinal disorders, necessitating the development of tailored monitoring strategies. Cervical spinal stenosis presents complex clinical symptoms and carries significant surgical risks, creating a critical need to clarify the monitoring features, alert patterns, and their relationship with outcomes in such surgeries. A comprehensive assessment and the development of a refined IONM monitoring plan throughout the perioperative period is an important direction for future research.

Purpose: This study aims to investigate the influencing factors of intraoperative neurophysiological monitoring (IONM) alarm events in patients with cervical spinal canal stenosis and to evaluate the predictive value of different IONM alarm patterns on neurological recovery following decompression surgery.

Design: Retrospective study PATIENT SAMPLES: This analysis included 1,622 patients who underwent cervical spinal canal decompression surgery and had complete IONM monitoring data between February 2017 and December 2022.

Outcome measures: The preoperative and postoperative neurological status of the patients was assessed using the modified Japanese Orthopaedic Association (mJOA) score. The primary IONM alarm indicators included somatosensory evoked potentials (SSEP) and transcranial motor evoked potentials (MEP), compared to the preoperative baseline.

Methods: Logistic regression was employed to analyze the correlation between preoperative diagnostic risk factors and intraoperative alarm events. Additionally, a multifactorial interaction analysis was performed to determine the relationship between IONM changes and the reversibility of alarms with the six-month mJOA recovery rate.

Results: Preoperative diagnoses of the ligamentum flavum hypertrophy and/or ossification of the posterior longitudinal ligament, combined with an mJOA score <12, were identified as high-risk factors for intraoperative alarms. The sensitivity of alarms in the high-risk group was 100%, with a positive predictive value of 90.6%; in the low-risk group, the sensitivity was 91.7%, with a positive predictive value of 40.74%. Variance analysis indicated that the mJOA improvement rate at six months was significantly lower in patients with irreversible IONM alarms compared to those with reversible alarms. Interaction analysis suggested that the reversibility of intraoperative alarm events was a principal predictor of postoperative outcomes, while risk factors for alarms had predictive value only in patients with irreversible alarms.

Conclusions: In patients with cervical spinal canal stenosis caused by disc degeneration, the presence of ligamentum flavum hypertrophy, ossification of the posterior longitudinal ligament, and preoperative mJOA scores <12 are significant high-risk factors for intraoperative alarms. The sensitivity and positive predictive value of intraoperative alarms in the high-risk group were significantly higher than those in the low-risk group. Moreover, patients with irreversible alarms exhibited poorer prognoses compared to those with reversible alarms, and preoperative alarm risk factors should not be considered independent predictors of patient outcomes.

术中神经生理监测在颈椎管狭窄减压术中的应用价值。
背景背景:尽管术中神经生理监测(IONM)已被广泛认可并应用于脊柱外科,但其特点因脊柱疾病类型而异,需要制定量身定制的监测策略。颈椎管狭窄症临床症状复杂,手术风险大,迫切需要明确此类手术的监测特征、预警模式及其与预后的关系。全面评估并制定完善的围手术期IONM监测计划是未来研究的重要方向。目的:探讨颈椎管狭窄患者术中神经生理监测(IONM)报警事件的影响因素,评价不同IONM报警模式对减压术后神经功能恢复的预测价值。患者样本:该分析包括1,622例患者,他们在2017年2月至2022年12月期间接受了颈椎管减压手术,并有完整的IONM监测数据。结果测量:使用改良的日本骨科协会(mJOA)评分评估患者术前和术后神经系统状态。与术前基线相比,主要IONM报警指标包括体感诱发电位(SSEP)和经颅运动诱发电位(MEP)。方法:采用Logistic回归分析术前诊断危险因素与术中报警事件的相关性。此外,还进行了多因素相互作用分析,以确定IONM变化与6个月mJOA恢复率报警可逆性之间的关系。结果:术前诊断黄韧带肥大和/或后纵韧带骨化,结合mJOA评分。结论:椎间盘退变所致颈椎管狭窄患者,黄韧带肥大、后纵韧带骨化与术前mJOA评分相关
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来源期刊
Spine Journal
Spine Journal 医学-临床神经学
CiteScore
8.20
自引率
6.70%
发文量
680
审稿时长
13.1 weeks
期刊介绍: The Spine Journal, the official journal of the North American Spine Society, is an international and multidisciplinary journal that publishes original, peer-reviewed articles on research and treatment related to the spine and spine care, including basic science and clinical investigations. It is a condition of publication that manuscripts submitted to The Spine Journal have not been published, and will not be simultaneously submitted or published elsewhere. The Spine Journal also publishes major reviews of specific topics by acknowledged authorities, technical notes, teaching editorials, and other special features, Letters to the Editor-in-Chief are encouraged.
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