The intersections between neuroscience and medulloblastoma

IF 9.1 1区医学 Q1 ONCOLOGY

Cancer letters Pub Date : 2025-03-26 DOI:10.1016/j.canlet.2025.217660

Yafei Wang , Ying Yu , Jiahua Yu , Cheng Wang , Yunkun Wang , Runxi Fu , Chenran Zhang

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引用次数: 0

Abstract

Medulloblastoma (MB) represents the most common malignant central nervous system tumor in childhood. The nervous system plays a critical role in the progression of MB, with interactions between the nervous system and cancer significantly influencing oncogenesis, tumor growth, invasion, stemness, and metabolism. These interactions also regulate angiogenesis, metastatic dissemination, the tumor immune microenvironment, and drug resistance. Investigating the nervous system-MB axis holds promise for identifying diagnostic markers, prognostic biomarkers, and therapeutic targets. It also provides insights into the molecular mechanisms underlying MB and informs the development of novel therapeutic strategies.

This review summarizes the latest advancements in understanding the interplay between the nervous system and MB, including the role of glial cells in MB and the potential of drug repurposing targeting nervous system components for MB treatment. These findings underscore promising diagnostic and therapeutic opportunities for MB management. Additionally, we outline future research directions in neurosciences that may pave the way for innovative therapeutic approaches and deepen our understanding of this complex disease.

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神经科学与成神经管细胞瘤的交叉。

髓母细胞瘤是儿童时期最常见的中枢神经系统恶性肿瘤。神经系统在MB的进展中起关键作用，神经系统与肿瘤的相互作用显著影响肿瘤的发生、生长、侵袭、干性和代谢。这些相互作用还调节血管生成、转移性传播、肿瘤免疫微环境和耐药性。研究神经系统- mb轴有望确定诊断标志物，预后生物标志物和治疗靶点。它还为MB的分子机制提供了见解，并为新的治疗策略的发展提供了信息。本文综述了神经系统与MB之间相互作用的最新进展，包括神经胶质细胞在MB中的作用以及靶向神经系统成分的药物靶向治疗MB的潜力。这些发现强调了MB管理的有希望的诊断和治疗机会。此外，我们概述了未来神经科学的研究方向，这可能为创新的治疗方法铺平道路，并加深我们对这种复杂疾病的理解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer letters 医学-肿瘤学

CiteScore

17.70

自引率

2.10%

发文量

427

审稿时长

15 days

期刊介绍： Cancer Letters is a reputable international journal that serves as a platform for significant and original contributions in cancer research. The journal welcomes both full-length articles and Mini Reviews in the wide-ranging field of basic and translational oncology. Furthermore, it frequently presents Special Issues that shed light on current and topical areas in cancer research. Cancer Letters is highly interested in various fundamental aspects that can cater to a diverse readership. These areas include the molecular genetics and cell biology of cancer, radiation biology, molecular pathology, hormones and cancer, viral oncology, metastasis, and chemoprevention. The journal actively focuses on experimental therapeutics, particularly the advancement of targeted therapies for personalized cancer medicine, such as metronomic chemotherapy. By publishing groundbreaking research and promoting advancements in cancer treatments, Cancer Letters aims to actively contribute to the fight against cancer and the improvement of patient outcomes.