Temporal and demographic disparities in mortality trends for heart failure and COPD-associated heart failure in U.S. Adults: A 1999–2020 analysis of CDC WONDER data

IF 2.3 4区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Cardiovascular Pathology Pub Date : 2025-03-26 DOI:10.1016/j.carpath.2025.107735

Faizan Ahmed , Tehmasp Rehman Mirza , Sherif Eltawansy , Zoha Khan , Yusra Mashkoor , Najam Gohar , Hira Zahid , Kainat Aman , Zaima Afzaal , Mushood Ahmed , Hritvik Jain , Aman Ullah , Nisar Asmi , Farman Ali , Adnan Bhat , Paweł Łajczak , Ogechukwu Obi , Muhammad Owais , Naveen Baskaran

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引用次数: 0

Abstract

Background

Heart failure (HF) carries varying mortality based on demographic distribution. Moreover, the interaction of HF with chronic obstructive pulmonary disease (COPD) raises this mortality. In this study, implementing national databases over a long time could assist in understanding mortality rates in patients suffering from two significant chronic diseases, HF and COPD.

Methods

This analysis utilized the CDC WONDER (Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research) system to assess the mortality trends between HF and COPD-associated HF in US adults aged 25–85+ from 1999 to 2020.

Results

This investigation detected a total of 6,755,700 deaths occurred in patients with HF in ages above 25. Fatalities of 1,141,819 (16.9 %) were associated with HF and comorbid COPD. Age-adjusted mortality Rates (AAMR) of HF-related deaths decreased from 162.7 to 154.4. (Average Annual Percentage Changes (AAPC): -0.49, 95 % CI: -0.63 to -0.34, p < 000001, while the overall AAMR for HF with COPD among adults increased from 24.5 in 1999 to 28.2 in 2020. Men had significantly higher HF-related AAMRs and HF with comorbid COPD-related mortality than women. HF-related AAMRs were highest among NH Black or African Americans, followed by NH Whites. At the same time, on the other side, HF and COPD had the highest mortality in non-Hispanic (NH) White individuals, followed by NH Black individuals, then Hispanic individuals. Mortality in HF with COPD was the highest in the Northeast, then the Midwest, South, and least in the West states.

Conclusion

Implementation of a CDC database provided guidance over two decades about the US population mortality attributed to HF with and without the presence of COPD, which contributed to a better understanding of national trends in prevailing diseases with remarkable chronicity.

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美国成年人心力衰竭和copd相关心力衰竭死亡率趋势的时间和人口差异：1999-2020年CDC WONDER数据分析

背景：心力衰竭（HF）的死亡率根据人口分布而变化。此外，心衰与慢性阻塞性肺疾病（COPD）的相互作用提高了这一死亡率。在这项研究中，在很长一段时间内实施国家数据库可以帮助了解患有HF和COPD两种重要慢性疾病的患者的死亡率。方法：本分析利用CDC WONDER（疾病控制和预防中心流行病学研究广泛在线数据）系统评估1999年至2020年美国25-85岁以上成年人心衰和copd相关性心衰之间的死亡率趋势。结果：本次调查发现，25岁以上的HF患者中共有6,755,700例死亡。死亡人数为1141819人（16.9%），与心衰和合并COPD相关。hf相关死亡的年龄调整死亡率（AAMR）从162.7降至154.4。（平均年变化百分比（AAPC）： -0.49, 95% CI: -0.63至-0.34）结论：CDC数据库的实施提供了20年来美国HF导致的人口死亡率的指导，这有助于更好地了解具有显著慢性疾病的国家流行趋势。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cardiovascular Pathology 医学-病理学

CiteScore

7.50

自引率

2.70%

发文量

审稿时长

18 days

期刊介绍： Cardiovascular Pathology is a bimonthly journal that presents articles on topics covering the entire spectrum of cardiovascular disease. The Journal''s primary objective is to publish papers on disease-oriented morphology and pathogenesis from clinicians and scientists in the cardiovascular field. Subjects covered include cardiovascular biology, prosthetic devices, molecular biology and experimental models of cardiovascular disease.