Common and specific effects in brain oscillations and motor symptoms of tDCS and tACS in Parkinson's disease.

IF 11.7 1区医学 Q1 CELL BIOLOGY

Cell Reports Medicine Pub Date : 2025-03-25 DOI:10.1016/j.xcrm.2025.102044

Jiafang Liu, Ying Zhu, Biao Chen, Qiujian Meng, Panpan Hu, Xianwen Chen, Junjie Bu

{"title":"Common and specific effects in brain oscillations and motor symptoms of tDCS and tACS in Parkinson's disease.","authors":"Jiafang Liu, Ying Zhu, Biao Chen, Qiujian Meng, Panpan Hu, Xianwen Chen, Junjie Bu","doi":"10.1016/j.xcrm.2025.102044","DOIUrl":null,"url":null,"abstract":"<p><p>Parkinson's disease (PD) leads to neurodegeneration and abnormal brain oscillations, causing motor dysfunction. Transcranial stimulation (transcranial direct current stimulation [tDCS]/transcranial alternating current stimulation [tACS]) may alleviate symptoms, but their oscillatory modulation mechanisms remain unclear. This randomized controlled trial (RCT) examines the effects of single-session tDCS/tACS on 60 PD patients, assigned to tDCS, tACS (20 Hz), or sham groups. Each receives 20-min left motor cortex stimulation while performing a simple reaction task. Open-source resting-state electroencephalogram (EEG) data reveal increased theta and decreased beta power in PD. In the RCT, tDCS and tACS enhance beta power, improving rigidity and bradykinesia. Additionally, tDCS reduces theta power, specifically alleviating tremor symptoms. Notably, the theta/beta ratio predicts and mediates tremor changes induced by tDCS more effectively than theta power alone. This sutdy revealed that tDCS broadly modulates oscillations, improving multiple symptoms, while tACS targets a single oscillation for specific symptom relief, emphasizing the crucial role of diverse oscillations in PD motor pathophysiology. This study was registered at ClinicalTrials.gov (NCT05678725).</p>","PeriodicalId":9822,"journal":{"name":"Cell Reports Medicine","volume":" ","pages":"102044"},"PeriodicalIF":11.7000,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell Reports Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.xcrm.2025.102044","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Parkinson's disease (PD) leads to neurodegeneration and abnormal brain oscillations, causing motor dysfunction. Transcranial stimulation (transcranial direct current stimulation [tDCS]/transcranial alternating current stimulation [tACS]) may alleviate symptoms, but their oscillatory modulation mechanisms remain unclear. This randomized controlled trial (RCT) examines the effects of single-session tDCS/tACS on 60 PD patients, assigned to tDCS, tACS (20 Hz), or sham groups. Each receives 20-min left motor cortex stimulation while performing a simple reaction task. Open-source resting-state electroencephalogram (EEG) data reveal increased theta and decreased beta power in PD. In the RCT, tDCS and tACS enhance beta power, improving rigidity and bradykinesia. Additionally, tDCS reduces theta power, specifically alleviating tremor symptoms. Notably, the theta/beta ratio predicts and mediates tremor changes induced by tDCS more effectively than theta power alone. This sutdy revealed that tDCS broadly modulates oscillations, improving multiple symptoms, while tACS targets a single oscillation for specific symptom relief, emphasizing the crucial role of diverse oscillations in PD motor pathophysiology. This study was registered at ClinicalTrials.gov (NCT05678725).

查看原文本刊更多论文

求助全文

约1分钟内获得全文求助全文

来源期刊

Cell Reports Medicine Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)

CiteScore

15.00

自引率

1.40%

发文量

231

审稿时长

40 days

期刊介绍： Cell Reports Medicine is an esteemed open-access journal by Cell Press that publishes groundbreaking research in translational and clinical biomedical sciences, influencing human health and medicine. Our journal ensures wide visibility and accessibility, reaching scientists and clinicians across various medical disciplines. We publish original research that spans from intriguing human biology concepts to all aspects of clinical work. We encourage submissions that introduce innovative ideas, forging new paths in clinical research and practice. We also welcome studies that provide vital information, enhancing our understanding of current standards of care in diagnosis, treatment, and prognosis. This encompasses translational studies, clinical trials (including long-term follow-ups), genomics, biomarker discovery, and technological advancements that contribute to diagnostics, treatment, and healthcare. Additionally, studies based on vertebrate model organisms are within the scope of the journal, as long as they directly relate to human health and disease.