PCD-CT Versus EID-CT in Imaging of Pancreatic Ductal Adenocarcinoma: A Prospective Comparative Pilot Study.

IF 1.6 4区医学 Q4 ONCOLOGY

Anticancer research Pub Date : 2025-04-01 DOI:10.21873/anticanres.17536

Hakon Blomstrand, Erik Tesselaar, Bergthor Björnsson, Wolf Bartholomä, Tomas Bjerner, Michael Sandborg, Nils O Elander, Mischa Woisetschläger

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引用次数: 0

Abstract

Background/aim: Photon-counting detector computerised tomography (PCD-CT) is a novel imaging technique that may be beneficial in diagnostics and follow-up of pancreatic ductal adenocarcinoma (PDAC).

Patients and methods: A prospective pilot including eight patients with confirmed PDAC was designed. Patients underwent conventional energy integrating detector CT (EID-CT) and PCD-CT, and corresponding arterial and venous phase images were compared in quantitative and qualitative manners. Five independent and method blinded reviewers scored each intra-individual pair of images.

Results: Quantitative assessment showed an advantage favouring PCD-CT in terms of signal to noise ratio (SNR) in aortic, pancreatic, and PDAC tissue (p=0.003, 0.001, and 0.040, respectively). There was a non-significant tendency towards better edge sharpness in the PCD-CT images. Qualitative assessments of image quality revealed minor differences in some aspects of arterial phase, favouring the conventional EID-CT, however no statistically significant differences in terms of overall or venous phase parameters between the methods were evident.

Conclusion: PCD-CT offers a novel method with potential benefits in imaging of pancreatic tumours. Further development of the protocol, including optimisation and validation in larger cohorts of patients, are necessary to define a potential role of PCD-CT in the management of PDAC.

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PCD-CT 与 EID-CT 在胰腺导管腺癌成像中的应用：一项前瞻性对比试验研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Anticancer research 医学-肿瘤学

CiteScore

3.70

自引率

10.00%

发文量

566

审稿时长

2 months

期刊介绍： ANTICANCER RESEARCH is an independent international peer-reviewed journal devoted to the rapid publication of high quality original articles and reviews on all aspects of experimental and clinical oncology. Prompt evaluation of all submitted articles in confidence and rapid publication within 1-2 months of acceptance are guaranteed. ANTICANCER RESEARCH was established in 1981 and is published monthly (bimonthly until the end of 2008). Each annual volume contains twelve issues and index. Each issue may be divided into three parts (A: Reviews, B: Experimental studies, and C: Clinical and Epidemiological studies). Special issues, presenting the proceedings of meetings or groups of papers on topics of significant progress, will also be included in each volume. There is no limitation to the number of pages per issue.