PCD-CT Versus EID-CT in Imaging of Pancreatic Ductal Adenocarcinoma: A Prospective Comparative Pilot Study.

IF 1.6 4区医学 Q4 ONCOLOGY

Anticancer research Pub Date : 2025-04-01 DOI:10.21873/anticanres.17536

Hakon Blomstrand, Erik Tesselaar, Bergthor Björnsson, Wolf Bartholomä, Tomas Bjerner, Michael Sandborg, Nils O Elander, Mischa Woisetschläger

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引用次数: 0

Abstract

Background/aim: Photon-counting detector computerised tomography (PCD-CT) is a novel imaging technique that may be beneficial in diagnostics and follow-up of pancreatic ductal adenocarcinoma (PDAC).

Patients and methods: A prospective pilot including eight patients with confirmed PDAC was designed. Patients underwent conventional energy integrating detector CT (EID-CT) and PCD-CT, and corresponding arterial and venous phase images were compared in quantitative and qualitative manners. Five independent and method blinded reviewers scored each intra-individual pair of images.

Results: Quantitative assessment showed an advantage favouring PCD-CT in terms of signal to noise ratio (SNR) in aortic, pancreatic, and PDAC tissue (p=0.003, 0.001, and 0.040, respectively). There was a non-significant tendency towards better edge sharpness in the PCD-CT images. Qualitative assessments of image quality revealed minor differences in some aspects of arterial phase, favouring the conventional EID-CT, however no statistically significant differences in terms of overall or venous phase parameters between the methods were evident.

Conclusion: PCD-CT offers a novel method with potential benefits in imaging of pancreatic tumours. Further development of the protocol, including optimisation and validation in larger cohorts of patients, are necessary to define a potential role of PCD-CT in the management of PDAC.

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PCD-CT 与 EID-CT 在胰腺导管腺癌成像中的应用：一项前瞻性对比试验研究。

背景/目的：光子计数检测器计算机断层扫描（PCD-CT）是一种新的成像技术，可能有助于胰腺导管腺癌（PDAC）的诊断和随访。患者和方法：设计了一项前瞻性试验，包括8名确诊的PDAC患者。对患者行常规能量积分CT （EID-CT）和PCD-CT检查，并对相应的动脉相和静脉相图像进行定量和定性比较。五名独立和方法盲的评论者对每个个体内的图像进行评分。结果：定量评估显示，在主动脉、胰腺和PDAC组织的信噪比（SNR）方面，PCD-CT具有优势（p分别=0.003、0.001和0.040）。在PCD-CT图像中，有一种不显著的趋向于更好的边缘清晰度。图像质量的定性评估显示，在动脉期的某些方面存在微小差异，有利于传统的EID-CT，但在总体或静脉期参数方面，两种方法之间没有明显的统计学差异。结论：PCD-CT为胰腺肿瘤的成像提供了一种具有潜在优势的新方法。该方案的进一步发展，包括在更大的患者队列中进行优化和验证，对于确定PCD-CT在PDAC管理中的潜在作用是必要的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Anticancer research 医学-肿瘤学

CiteScore

3.70

自引率

10.00%

发文量

566

审稿时长

2 months

期刊介绍： ANTICANCER RESEARCH is an independent international peer-reviewed journal devoted to the rapid publication of high quality original articles and reviews on all aspects of experimental and clinical oncology. Prompt evaluation of all submitted articles in confidence and rapid publication within 1-2 months of acceptance are guaranteed. ANTICANCER RESEARCH was established in 1981 and is published monthly (bimonthly until the end of 2008). Each annual volume contains twelve issues and index. Each issue may be divided into three parts (A: Reviews, B: Experimental studies, and C: Clinical and Epidemiological studies). Special issues, presenting the proceedings of meetings or groups of papers on topics of significant progress, will also be included in each volume. There is no limitation to the number of pages per issue.