Rishika P Sakaria, Divya Rana, Mimily Harsono, Harris L Cohen, Massroor Pourcyrous
{"title":"Head Ultrasound Findings in Infants with Birth Weight >1,500 g and Gestational Age >32 Weeks Exposed to Prenatal Opioids.","authors":"Rishika P Sakaria, Divya Rana, Mimily Harsono, Harris L Cohen, Massroor Pourcyrous","doi":"10.1055/a-2552-0715","DOIUrl":null,"url":null,"abstract":"<p><p>This study aimed to evaluate the effects of prenatal exposure to opioids on head ultrasound (HUS) and to determine the need for routine HUS evaluation in infants exposed to prenatal opioids.This is a retrospective cohort study performed at a level III NICU. Infants >32 weeks gestational age and >1,500 g birth weight with prenatal opioid exposure (<i>n</i> = 127) were included in this study. Data including demographic information and HUS results were recorded.Twenty (16%) infants were exposed to opioids only whereas the rest of the infants (84%) were exposed to opioids plus other drugs (polysubstance) in utero. Sixteen of 127 infants (13%) had abnormal initial HUS. Sub-ependymal hemorrhage or grade 1 intraventricular hemorrhage was the most common abnormal finding. Absent septum pellucidum was seen in three infants.A relatively large proportion (13%) of infants in this study had abnormal HUS findings; however, further studies are required to correlate HUS findings with a specific drug of exposure, duration of exposure, polysubstance use, umbilical cord drug concentration levels, and neurodevelopmental outcomes. · Limited data exists regarding HUS findings in infants with prenatal opioid exposure.. · A relatively large proportion of infants exposed to opioids in utero had abnormal HUS.. · Subependymal hemorrhages or grade I intraventricular hemorrhage was the most common abnormal finding..</p>","PeriodicalId":7584,"journal":{"name":"American journal of perinatology","volume":" ","pages":""},"PeriodicalIF":1.5000,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"American journal of perinatology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1055/a-2552-0715","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
This study aimed to evaluate the effects of prenatal exposure to opioids on head ultrasound (HUS) and to determine the need for routine HUS evaluation in infants exposed to prenatal opioids.This is a retrospective cohort study performed at a level III NICU. Infants >32 weeks gestational age and >1,500 g birth weight with prenatal opioid exposure (n = 127) were included in this study. Data including demographic information and HUS results were recorded.Twenty (16%) infants were exposed to opioids only whereas the rest of the infants (84%) were exposed to opioids plus other drugs (polysubstance) in utero. Sixteen of 127 infants (13%) had abnormal initial HUS. Sub-ependymal hemorrhage or grade 1 intraventricular hemorrhage was the most common abnormal finding. Absent septum pellucidum was seen in three infants.A relatively large proportion (13%) of infants in this study had abnormal HUS findings; however, further studies are required to correlate HUS findings with a specific drug of exposure, duration of exposure, polysubstance use, umbilical cord drug concentration levels, and neurodevelopmental outcomes. · Limited data exists regarding HUS findings in infants with prenatal opioid exposure.. · A relatively large proportion of infants exposed to opioids in utero had abnormal HUS.. · Subependymal hemorrhages or grade I intraventricular hemorrhage was the most common abnormal finding..
期刊介绍:
The American Journal of Perinatology is an international, peer-reviewed, and indexed journal publishing 14 issues a year dealing with original research and topical reviews. It is the definitive forum for specialists in obstetrics, neonatology, perinatology, and maternal/fetal medicine, with emphasis on bridging the different fields.
The focus is primarily on clinical and translational research, clinical and technical advances in diagnosis, monitoring, and treatment as well as evidence-based reviews. Topics of interest include epidemiology, diagnosis, prevention, and management of maternal, fetal, and neonatal diseases. Manuscripts on new technology, NICU set-ups, and nursing topics are published to provide a broad survey of important issues in this field.
All articles undergo rigorous peer review, with web-based submission, expedited turn-around, and availability of electronic publication.
The American Journal of Perinatology is accompanied by AJP Reports - an Open Access journal for case reports in neonatology and maternal/fetal medicine.