Effect of vitamin D on anterior cruciate ligament injury rates and post-reconstruction function—A systematic review

IF 2 Q2 ORTHOPEDICS

Journal of Experimental Orthopaedics Pub Date : 2025-04-01 DOI:10.1002/jeo2.70224

Andrea Pasquini, Radu Prejbeanu, Octav Russu, Riccardo D'Ambrosi, Cosmin Ioan Faur, Giulio Maria Marcheggiani Muccioli, Mihail Lazar Mioc

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Abstract

Purpose

This systematic review aimed to investigate the association between serum vitamin D levels and key outcomes following anterior cruciate ligament reconstruction (ACLR), including ACL injury risk, postoperative muscle recovery and post-reconstruction functional outcomes.

Methods

We conducted a comprehensive search across five databases (Cochrane Library, EMBASE, MEDLINE, Scopus and Web of Science) until July 2024. Studies were selected based on specific inclusion criteria, such as studies evaluating the relationship between vitamin D and injury risk, ACLR outcomes and muscle strength. Risk of bias was assessed using the MINORS tool, and results were synthesized narratively due to study heterogeneity.

Results

Five studies with 656,243 participants met the inclusion criteria. Most studies reported that low vitamin D levels were associated with a significantly increased risk of ACL injuries and poorer postoperative muscle strength recovery. However, evidence regarding bone health and functional outcomes was inconsistent. No meta-analysis was conducted due to the variability of study designs and outcomes, but qualitative synthesis indicated a potential protective role of vitamin D in ACL recovery.

Conclusions

Vitamin D deficiency appears to increase the risk of ACL injury and impede muscle recovery post-surgery. However, limitations include a high risk of bias and inconsistent evidence on functional outcomes, underscoring the need for further research. The review was registered in PROSPERO (ID: CRD42024584483).