MOF-253·Cu(OAc)2 as a heterogeneous catalyst for N-arylation of heterocycles

Abstract

A Cu(OAc)₂ immobilized on MOF-253 complex (MOF-253·Cu(OAc)₂) was constructed that exhibits efficient catalytic activity for the Ullmann-type CN cross-coupling reactions. N-arylation of imidazoles, pyrazole, pyrrole and 1,2,4-triazole with aryl iodides have been achieved to afford the desired coupling products in good yields over 33 examples. The catalyst could be easily prepared and reused for several times without the decreasing catalytic efficiency, as well as low metal leaching in the reaction solution, which all make the process much more practical.