Cancer neuroscience in head and neck: interactions, modulation, and therapeutic strategies

IF 27.7 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Cancer Pub Date : 2025-03-31 DOI:10.1186/s12943-025-02299-6

Hanrui Wang, Xiaoyu Song, Hui Shen, Wanchen Liu, Yao Wang, Mingjun Zhang, Ting Yang, Yakui Mou, Chao Ren, Xicheng Song

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Abstract

Head and neck cancer (HNC) is an aggressive malignancy with significant effects on the innervation. Not only is it at the top of the cancer spectrum with a dismal prognosis, but it also imposes considerable stress on patients and society owing to frequent neurological symptoms. With progress in cancer neuroscience, the interactions between HNC and the nervous system, as well as the underlying mechanisms, have become increasingly clear. Compelling evidence suggests communication of information between cancer and nerve cells and devastation of the neurological system with tumor growth. However, the thorough grasp of HNC in cancer neuroscience has been severely constrained by the intricacy of HNC and fragmented research. This review comprehensively organizes and summarizes the latest research on the crosstalk between HNC and the nervous system. It aims to clarify various aspects of the neurological system in HNC, including the physiology, progression, and treatment of cancer. Furthermore, the opportunities and challenges of cancer neuroscience in HNC are discussed, which offers fresh perspectives on the neurological aspects of HNC diagnosis and management.

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头颈癌（HNC）是一种对神经支配有重大影响的侵袭性恶性肿瘤。它不仅是癌症中预后最差的一种，而且由于经常出现神经症状，给患者和社会带来了巨大的压力。随着癌症神经科学的发展，HNC 与神经系统之间的相互作用及其内在机制已变得越来越清晰。令人信服的证据表明，癌症与神经细胞之间存在信息交流，随着肿瘤的生长，神经系统也会受到破坏。然而，由于 HNC 的复杂性和研究的零散性，癌症神经科学对 HNC 的透彻把握受到严重制约。本综述全面整理和总结了有关 HNC 与神经系统之间相互影响的最新研究。它旨在阐明 HNC 神经系统的各个方面，包括癌症的生理、进展和治疗。此外，还讨论了癌症神经科学在 HNC 中的机遇和挑战，为 HNC 诊断和管理的神经方面提供了新的视角。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Cancer 医学-生化与分子生物学

CiteScore

54.90

自引率

2.70%

发文量

224

审稿时长

2 months

期刊介绍： Molecular Cancer is a platform that encourages the exchange of ideas and discoveries in the field of cancer research, particularly focusing on the molecular aspects. Our goal is to facilitate discussions and provide insights into various areas of cancer and related biomedical science. We welcome articles from basic, translational, and clinical research that contribute to the advancement of understanding, prevention, diagnosis, and treatment of cancer. The scope of topics covered in Molecular Cancer is diverse and inclusive. These include, but are not limited to, cell and tumor biology, angiogenesis, utilizing animal models, understanding metastasis, exploring cancer antigens and the immune response, investigating cellular signaling and molecular biology, examining epidemiology, genetic and molecular profiling of cancer, identifying molecular targets, studying cancer stem cells, exploring DNA damage and repair mechanisms, analyzing cell cycle regulation, investigating apoptosis, exploring molecular virology, and evaluating vaccine and antibody-based cancer therapies. Molecular Cancer serves as an important platform for sharing exciting discoveries in cancer-related research. It offers an unparalleled opportunity to communicate information to both specialists and the general public. The online presence of Molecular Cancer enables immediate publication of accepted articles and facilitates the presentation of large datasets and supplementary information. This ensures that new research is efficiently and rapidly disseminated to the scientific community.