Future liver remnant hypertrophy and postoperative outcomes: a retrospective comparison between segmental and main right portal vein embolization.

IF 1.2 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS
Elif Can, Aboelyazid Elkilany, Sophia Paparoditis, Bernhard Gebauer, Dominik Geisel, Felix Krenzien, Anne Pohrt, Wibke Uller, Michael Doppler, Sebastian Ebel, Holger Gößmann, Uli Fehrenbach
{"title":"Future liver remnant hypertrophy and postoperative outcomes: a retrospective comparison between segmental and main right portal vein embolization.","authors":"Elif Can, Aboelyazid Elkilany, Sophia Paparoditis, Bernhard Gebauer, Dominik Geisel, Felix Krenzien, Anne Pohrt, Wibke Uller, Michael Doppler, Sebastian Ebel, Holger Gößmann, Uli Fehrenbach","doi":"10.1186/s42155-025-00537-y","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To assess the efficacy of segmental right portal vein embolization (SRPVE) versus main right portal vein embolization (MRPVE) in preoperative preparation for major hepatectomy.</p><p><strong>Methods: </strong>This retrospective single-center study included 220 consecutive patients who underwent portal vein embolization (PVE) before (extended) right hemihepatectomy between January 2014 and June 2021. Seventy-one patients underwent selective segmental embolization (SRPVE) and 149 patients underwent MRPVE. Volumetric analysis was conducted before PVE and before surgery. Key endpoints included evaluation of future liver remnant (FLR) hypertrophy, intraoperative complexity, and postoperative complications, technical success, clinical success, complications (Clavien-Dindo and CIRSE classifications), as well as evaluation of different factors which may influence hypertrophy of the FLR.</p><p><strong>Results: </strong>Technical success rate was 100% in the SRPVE group and 99.3% in the MRPVE group (p = 0.15). Clinical success rate was comparable between both techniques, measuring 95.8% in the SRPVE group and 95.3% in the MRPVE group (p = 0.18). Absolute hypertrophy (FLRabh) of the FLR was comparable between both techniques, measuring 47.15% in the SRPVE group and 40.78% in the MRPVE group (p = 0.54). Complication rates did not differ significantly (p = 0.12). Partial thrombosis involving the left portal vein, main portal vein, or mesentericosplenic region was observed in 2.8% of the patients in the SRPVE group vs 3.4% in the MRPVE group (p = 0.95). CIRSE Class II-VI complications were slightly higher in the MRPVE group (10.7% vs 9.8%, p = 0.82). Postoperative complications with Clavien-Dindo class ≥ IIIa occurred in 10.1% % in the MRPVE group vs 9.9% the SRPVE group (p = 0.92). Liver cirrhosis had a significant negative correlation with sFLR % increase following PVE (r = -0.54; p = 0.027). Neoadjuvant chemotherapy was also associated with reduced FLR hypertrophy following PVE, with a median sFLR% change of 63.8% (IQR: 60.8% - 75.2%) in patients who received neoadjuvant chemotherapy (n = 66 patients, 30%) compared to 82.6% (IQR: 77.4% - 84.2%) in those without chemotherapy (n = 154 patients, 70%).</p><p><strong>Conclusion: </strong>Selective segmental right portal vein embolization, sparing the main right portal vein, offers a safe and effective alternative to MRPVE, achieving comparable FLR hypertrophy while potentially simplifying intraoperative procedures and reducing postprocedural complications. Future research should focus on conducting large, prospective, multicenter trials to further compare the long-term outcomes of this technique, particularly with regard to liver regeneration, postoperative liver function, complications and overall survival.</p>","PeriodicalId":52351,"journal":{"name":"CVIR Endovascular","volume":"8 1","pages":"27"},"PeriodicalIF":1.2000,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11950456/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"CVIR Endovascular","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1186/s42155-025-00537-y","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
引用次数: 0

Abstract

Objective: To assess the efficacy of segmental right portal vein embolization (SRPVE) versus main right portal vein embolization (MRPVE) in preoperative preparation for major hepatectomy.

Methods: This retrospective single-center study included 220 consecutive patients who underwent portal vein embolization (PVE) before (extended) right hemihepatectomy between January 2014 and June 2021. Seventy-one patients underwent selective segmental embolization (SRPVE) and 149 patients underwent MRPVE. Volumetric analysis was conducted before PVE and before surgery. Key endpoints included evaluation of future liver remnant (FLR) hypertrophy, intraoperative complexity, and postoperative complications, technical success, clinical success, complications (Clavien-Dindo and CIRSE classifications), as well as evaluation of different factors which may influence hypertrophy of the FLR.

Results: Technical success rate was 100% in the SRPVE group and 99.3% in the MRPVE group (p = 0.15). Clinical success rate was comparable between both techniques, measuring 95.8% in the SRPVE group and 95.3% in the MRPVE group (p = 0.18). Absolute hypertrophy (FLRabh) of the FLR was comparable between both techniques, measuring 47.15% in the SRPVE group and 40.78% in the MRPVE group (p = 0.54). Complication rates did not differ significantly (p = 0.12). Partial thrombosis involving the left portal vein, main portal vein, or mesentericosplenic region was observed in 2.8% of the patients in the SRPVE group vs 3.4% in the MRPVE group (p = 0.95). CIRSE Class II-VI complications were slightly higher in the MRPVE group (10.7% vs 9.8%, p = 0.82). Postoperative complications with Clavien-Dindo class ≥ IIIa occurred in 10.1% % in the MRPVE group vs 9.9% the SRPVE group (p = 0.92). Liver cirrhosis had a significant negative correlation with sFLR % increase following PVE (r = -0.54; p = 0.027). Neoadjuvant chemotherapy was also associated with reduced FLR hypertrophy following PVE, with a median sFLR% change of 63.8% (IQR: 60.8% - 75.2%) in patients who received neoadjuvant chemotherapy (n = 66 patients, 30%) compared to 82.6% (IQR: 77.4% - 84.2%) in those without chemotherapy (n = 154 patients, 70%).

Conclusion: Selective segmental right portal vein embolization, sparing the main right portal vein, offers a safe and effective alternative to MRPVE, achieving comparable FLR hypertrophy while potentially simplifying intraoperative procedures and reducing postprocedural complications. Future research should focus on conducting large, prospective, multicenter trials to further compare the long-term outcomes of this technique, particularly with regard to liver regeneration, postoperative liver function, complications and overall survival.

求助全文
约1分钟内获得全文 求助全文
来源期刊
CVIR Endovascular
CVIR Endovascular Medicine-Radiology, Nuclear Medicine and Imaging
CiteScore
2.30
自引率
0.00%
发文量
59
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信