Associations among PM2.5, corticotropin releasing hormone, estriol, and progesterone in pregnant persons in Puerto Rico.

IF 2.5 4区 环境科学与生态学 Q3 ENVIRONMENTAL SCIENCES
Environmental Research Communications Pub Date : 2025-03-01 Epub Date: 2025-03-26 DOI:10.1088/2515-7620/adc0f1
Trenton Honda, Trenton Henry, Christina A Porucznik, Laura Corlin, Kipruto Kirwa, Akram Alshawabkeh, José F Cordero, Carmen M Velez Vega, Zaira Y Rosario Pabon, John D Meeker, Helen Suh
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Abstract

Background. Exposure to PM2.5 is associated with adverse birth outcomes and early development. Pregnancy is typically characterized by the production of several important hormones that impact aspects of maternal and fetal physiology, including progesterone, estriol, and corticotropin releasing hormone (CRH). No previous studies have examined PM associations in pregnant persons for CRH and estriol. Methods. We used linear mixed effects models to investigate associations between PM2.5 and pregnancy hormones in 1,041 pregnant persons ages 18-41 living in Puerto Rico between 2011 and 2020. Individual 3-, 7-, and 30-day moving average exposures were assigned from EPA data sources. Hormone levels were analyzed in blood collected at study visits at 16-20 and 20-24 weeks of gestation. Models were adjusted for demographics, socioeconomic status, and health behaviors.Results. Mean participant exposures for 3-, 7-, and 30-day PM2.5 were 8.0 ± 5.9, 8.2 ± 5.3, and 8.1 ± 4.4 μg m-3. In base models, increased PM2.5 exposure was associated with lower levels of progesterone, CRH, and estriol. In adjusted models, 10 μg m-3 increase in PM2.5 was associated with 11.2% (95% CI: 17.6, 4.3; p = 0.003) and 14.9% (95% CI: 23.4, 5.4; p = 0.004) lower CRH for 7-day and 30-day exposures. In cross-sectional models, the inverse CRH association was driven by the 20-24 week gestation period with a 12.4% reduction (95% CI: 21.8, 1.9; p = 0.022) for 7-day and 17.5% reduction (95% CI: 29.7, 3.0; p = 0.020) for 30-day exposure. Other investigated associations were null.Conclusions. In pregnant persons in Puerto Rico, we observed that elevated PM2.5 exposures were significantly associated with decrements in CRH, but not in other pregnancy-associated hormones. CRH may be an important pathway through which prenatal PM2.5 impacts normal pregnancy.

波多黎各孕妇PM2.5、促肾上腺皮质激素释放激素、雌三醇和黄体酮之间的关系。
背景。暴露于PM2.5与不良的出生结果和早期发育有关。妊娠的典型特征是产生几种影响母体和胎儿生理方面的重要激素,包括黄体酮、雌三醇和促肾上腺皮质激素释放激素(CRH)。没有先前的研究检查PM与孕妇CRH和雌三醇的关系。方法。我们使用线性混合效应模型调查了2011年至2020年间居住在波多黎各的1041名18-41岁孕妇的PM2.5与妊娠激素之间的关系。个体的3天、7天和30天移动平均暴露量从EPA数据来源中分配。在妊娠16-20周和20-24周研究访问时收集血液中的激素水平进行分析。模型根据人口统计学、社会经济地位和健康行为进行了调整。3天、7天和30天PM2.5的平均暴露量分别为8.0±5.9、8.2±5.3和8.1±4.4 μg - m-3。在基础模型中,PM2.5暴露增加与孕酮、促红细胞生成素和雌三醇水平降低有关。在调整后的模型中,PM2.5增加10 μg m-3与11.2%相关(95% CI: 17.6, 4.3;p = 0.003)和14.9% (95% CI: 23.4, 5.4;p = 0.004)暴露7天和30天的CRH较低。在横断面模型中,CRH负相关由妊娠20-24周驱动,降低12.4% (95% CI: 21.8, 1.9;p = 0.022),减少17.5% (95% CI: 29.7, 3.0;P = 0.020)。其他调查的关联为零。在波多黎各的孕妇中,我们观察到PM2.5暴露的升高与CRH的降低显著相关,但与其他妊娠相关激素无关。CRH可能是产前PM2.5影响正常妊娠的重要途径。
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来源期刊
Environmental Research Communications
Environmental Research Communications ENVIRONMENTAL SCIENCES-
CiteScore
3.50
自引率
0.00%
发文量
136
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