{"title":"Adherence unveiled: A concept analysis of medication adherence in adult patients with sickle cell disease.","authors":"Eva Okereke-Enechukwu","doi":"10.1097/JXX.0000000000001130","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Patients with sickle cell disease (SCD) require lifelong adherence to treatment protocols, significantly affecting their care quality. Despite effective disease-modifying drug therapies (DMDTs), adherence remains suboptimal, with 30%-60% of patients being nonadherent. Ensuring medication adherence is crucial to attain the intended outcomes of DMDTs in patients with SCD.</p><p><strong>Purpose: </strong>This article examines the concept of \"medication adherence\" in adult patients with SCD undergoing DMDTs, offering fresh insights, knowledge, and clarity regarding the concept.</p><p><strong>Methodology: </strong>Walker and Avant's methods for concept analysis were employed to establish attributes, antecedents, consequences, and empirical referents of adherence in adult patients with SCD on DMDTs. A thorough literature search of PubMed, Cochrane Library, and CINAHL was conducted, encompassing peer-reviewed articles published in English from 2009 to 2023, using keywords and Boolean operators pertinent to adherence and SCD.</p><p><strong>Results: </strong>Following the literature search, 55 articles were identified, with 29 excluded based on title and abstract. The eligibility process narrowed the count to 15 pertinent articles included in this concept analysis. Attributes, antecedents, and consequences were synthesized to formulate a definition well-founded in the literature.</p><p><strong>Conclusions: </strong>Adherence is crucial in health care and offers an opportunity for interventions to improve patient outcomes. Understanding adherence to treatment protocols is vital for health care providers and researchers, and it should be further integrated into research and practice to improve the quality of life for patients with SCD.</p><p><strong>Implications: </strong>Integrating SCD medication adherence into nursing education and continuing education has the potential to enhance clinical interventions, improve patient outcomes, and refine nursing practice.</p>","PeriodicalId":17179,"journal":{"name":"Journal of the American Association of Nurse Practitioners","volume":" ","pages":""},"PeriodicalIF":1.2000,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the American Association of Nurse Practitioners","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/JXX.0000000000001130","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Patients with sickle cell disease (SCD) require lifelong adherence to treatment protocols, significantly affecting their care quality. Despite effective disease-modifying drug therapies (DMDTs), adherence remains suboptimal, with 30%-60% of patients being nonadherent. Ensuring medication adherence is crucial to attain the intended outcomes of DMDTs in patients with SCD.
Purpose: This article examines the concept of "medication adherence" in adult patients with SCD undergoing DMDTs, offering fresh insights, knowledge, and clarity regarding the concept.
Methodology: Walker and Avant's methods for concept analysis were employed to establish attributes, antecedents, consequences, and empirical referents of adherence in adult patients with SCD on DMDTs. A thorough literature search of PubMed, Cochrane Library, and CINAHL was conducted, encompassing peer-reviewed articles published in English from 2009 to 2023, using keywords and Boolean operators pertinent to adherence and SCD.
Results: Following the literature search, 55 articles were identified, with 29 excluded based on title and abstract. The eligibility process narrowed the count to 15 pertinent articles included in this concept analysis. Attributes, antecedents, and consequences were synthesized to formulate a definition well-founded in the literature.
Conclusions: Adherence is crucial in health care and offers an opportunity for interventions to improve patient outcomes. Understanding adherence to treatment protocols is vital for health care providers and researchers, and it should be further integrated into research and practice to improve the quality of life for patients with SCD.
Implications: Integrating SCD medication adherence into nursing education and continuing education has the potential to enhance clinical interventions, improve patient outcomes, and refine nursing practice.
期刊介绍：
The Journal of the American Association of Nurse Practitioners (JAANP) is a monthly peer-reviewed professional journal that serves as the official publication of the American Association of Nurse Practitioners.
Published since 1989, the JAANP provides a strong clinical focus with articles related to primary, secondary, and tertiary care, nurse practitioner education, health policy, ethics and ethical issues, and health care delivery. The journal publishes original research, integrative/comprehensive reviews, case studies, a variety of topics in clinical practice, and theory-based articles related to patient and professional education. Although the majority of nurse practitioners function in primary care, there is an increasing focus on the provision of care across all types of systems from acute to long-term care settings.
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