Frequency-specific modulation of motor cortical excitability by transcranial alternating current stimulation.

IF 5.2 2区 医学 Q1 ENGINEERING, BIOMEDICAL
Lei Tingting, Chen Lilin, Wang Chuangjia, Si Jiamen, Zhang Shuxian, Ai Yinan, Liu Hanjun, Zheng Haiqing
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Abstract

Background: Transcranial alternating current stimulation (tACS) is a non-invasive technique that modulates neural oscillations, yet its specific effects on cortical excitability are not well-understood. This study investigated the effects of tACS on neuroplasticity in the primary motor cortex (M1) across different frequencies.

Methods: In this randomized, sham-controlled, crossover study, 18 healthy young adults received β-tACS γ-tACS, and sham stimulation over the M1. Neurophysiological responses were assessed using motor evoked potentials (MEPs), electroencephalograms (EEG), and transcranial evoked potentials (TEPs) to determine the frequency-specific effects of tACS on cortical excitability and neuroplasticity.

Results: γ-tACS significantly enhanced cortical excitability, as reflected by larger MEP amplitudes compared to both β-tACS and sham stimulation. In addition, γ-tACS resulted in significantly smaller M1-P15 amplitudes in TEP than other stimulation conditions. In contrast, β-tACS did not produce significant changes in either MEPs or TEPs compared to sham stimulation.

Conclusion: These findings provide evidence that tACS induces frequency-dependent effects on cortical excitability and neuroplasticity within the M1. This selective modulation of cortical excitability with γ-tACS suggests its potential as a therapeutic intervention for optimizing motor function and rehabilitation.

Trial registration: This study was registered in the Chinese Clinical Trial Registry (ChiCTR2300074898, date of registration: 2023/08/18).

经颅交流电刺激对运动皮层兴奋性的频率特异性调节。
背景:经颅交流电刺激(tACS)是一种调节神经振荡的非侵入性技术,但其对皮层兴奋性的具体影响尚不清楚。本研究探讨了不同频率的tACS对初级运动皮层(M1)神经可塑性的影响。方法:在这项随机、假对照、交叉研究中,18名健康青年接受β-tACS γ-tACS和假性M1刺激。使用运动诱发电位(MEPs)、脑电图(EEG)和经颅诱发电位(TEPs)评估神经生理反应,以确定tACS对皮层兴奋性和神经可塑性的频率特异性影响。结果:与β-tACS和假刺激相比,γ-tACS显著增强了皮质兴奋性,反映在更大的MEP振幅上。此外,γ-tACS导致TEP的M1-P15振幅明显小于其他刺激条件。相比之下,与假刺激相比,β-tACS在mep和tep中均未产生显著变化。结论:这些发现提供了证据,证明tACS在M1内诱导皮层兴奋性和神经可塑性的频率依赖效应。γ-tACS对皮质兴奋性的选择性调节表明,它有可能成为优化运动功能和康复的治疗干预手段。试验注册:本研究已在中国临床试验注册中心注册(ChiCTR2300074898,注册日期:2023/08/18)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of NeuroEngineering and Rehabilitation
Journal of NeuroEngineering and Rehabilitation 工程技术-工程:生物医学
CiteScore
9.60
自引率
3.90%
发文量
122
审稿时长
24 months
期刊介绍: Journal of NeuroEngineering and Rehabilitation considers manuscripts on all aspects of research that result from cross-fertilization of the fields of neuroscience, biomedical engineering, and physical medicine & rehabilitation.
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