Comparative Analyses Between Vulnerability Biomarkers of Aging and Health Biomarkers in Middle-Aged and Older Female Adults.

IF 2.4 4区 医学 Q2 HEALTH CARE SCIENCES & SERVICES
Klara Karin Brigitte Knoblauch, Luana Froes Losnack, Gustavo Castillo Zacarias, Gabriel Gasparini Satyro, Rodrigo Villar, Anderson Saranz Zago
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引用次数: 0

Abstract

Biological aging is normally associated with greater physiological changes which predispose individuals to adverse outcomes. In this way, the evaluation of vulnerability biomarkers and their relationships with other health biomarkers could contribute to the promotion of interventions and the improvement of older adults' quality of life. Thereby, this study aimed to compare vulnerability biomarkers (Growth Differentiation Factor 15 (GDF-15), General Functional Fitness Index (GFFI), and frailty phenotype) and their influence on health markers (blood biochemistry, body composition, and hemodynamic variables) in middle-aged and older female adults. Methods: A cross-sectional observational study was conducted with community-dwelling females aged 54-84 with at least 6 months of experience with physical training. The participants were categorized based on functional fitness, frailty phenotype, and GDF-15 quartiles. The General Functional Fitness Index (GFFI) was assessed using the AAHPERD test battery, while frailty phenotype was determined using Fried's criteria. GDF-15 levels were measured through ELISA. Results: A higher training status (TS) showed better functional fitness and favorable biochemical profiles, including lower total cholesterol (p = 0.006, η2p = 0.253), LDL cholesterol (p = 0.001, η2p = 0.346), triglycerides (p = 0.048, η2p = 0.195), and systolic blood pressure (p = 0.001, η2p = 0.333). Individuals classified as robust (non-frail) had better physical performance and lower total cholesterol (p = 0.002, η2p = 0.306) and LDL cholesterol (p = 0.014, η2p = 0.216) compared to those classified as frail and pre-frail. The GDF-15 quartile did not present differences in health markers between groups. Conclusions: These findings suggest that GFFI may be considered a health biomarker for middle-aged and female older adults while highlighting the need for further research on the role of biomarkers of vulnerability and healthy aging.

中老年女性衰老易损性生物标志物与健康生物标志物的比较分析
生物衰老通常与更大的生理变化有关,这些生理变化使个体容易产生不良后果。因此,脆弱性生物标志物的评估及其与其他健康生物标志物的关系可能有助于促进干预措施和改善老年人的生活质量。因此,本研究旨在比较中老年女性的易损性生物标志物(生长分化因子15 (GDF-15)、一般功能适应指数(GFFI)和脆弱表型)及其对健康标志物(血液生化、身体成分和血流动力学变量)的影响。方法:对54-84岁社区女性进行横断面观察研究,这些女性至少有6个月的体育训练经验。参与者根据功能适合度、脆弱表型和GDF-15四分位数进行分类。一般功能适应度指数(GFFI)使用AAHPERD测试电池进行评估,而脆弱表型使用Fried标准确定。ELISA法检测GDF-15水平。结果:高训练状态(TS)表现出较好的功能适应度和良好的生化指标,包括较低的总胆固醇(p = 0.006, η2p = 0.253)、低密度脂蛋白胆固醇(p = 0.001, η2p = 0.346)、甘油三酯(p = 0.048, η2p = 0.195)和收缩压(p = 0.001, η2p = 0.333)。与体弱和体弱前期的个体相比,体魄强健(非体弱)的个体表现更好,总胆固醇(p = 0.002, η2p = 0.306)和低密度脂蛋白胆固醇(p = 0.014, η2p = 0.216)也更低。GDF-15四分位数在各组之间的健康指标没有差异。结论:这些研究结果表明,GFFI可能被认为是中年和女性老年人的健康生物标志物,同时强调需要进一步研究生物标志物在脆弱性和健康衰老中的作用。
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来源期刊
Healthcare
Healthcare Medicine-Health Policy
CiteScore
3.50
自引率
7.10%
发文量
0
审稿时长
47 days
期刊介绍: Healthcare (ISSN 2227-9032) is an international, peer-reviewed, open access journal (free for readers), which publishes original theoretical and empirical work in the interdisciplinary area of all aspects of medicine and health care research. Healthcare publishes Original Research Articles, Reviews, Case Reports, Research Notes and Short Communications. We encourage researchers to publish their experimental and theoretical results in as much detail as possible. For theoretical papers, full details of proofs must be provided so that the results can be checked; for experimental papers, full experimental details must be provided so that the results can be reproduced. Additionally, electronic files or software regarding the full details of the calculations, experimental procedure, etc., can be deposited along with the publication as “Supplementary Material”.
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