Identifying predictors of worsening glycaemic outcomes in prediabetes: a two-year cohort study in Terengganu, Malaysia.

Q3 Medicine
Medical Journal of Malaysia Pub Date : 2025-03-01
N A Yusof, N A Idris, A Abdul Aziz, N N Naing, S S Oo, M M T Aung, M Z H Ismail, R Abdul Latif
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引用次数: 0

Abstract

Introduction: Prediabetes is a critical stage preceding diabetes mellitus (DM) which is also associated with an elevated risk of developing DM and related complications. Addressing predictors that influence the progression or regression of glycaemic outcomes in prediabetic individuals can enhance intervention strategies. This study aims to identify key predictors of glycaemic progression among adults with prediabetes in Terengganu, Malaysia.

Materials and methods: A retrospective cohort study was conducted involving 592 prediabetic adults from 28 health clinics in Terengganu between January 2019 and June 2023. Participants were selected based on oral glucose tolerance test (OGTT) results indicating prediabetes. Sociodemographic, medical background, and clinical data, including body mass index (BMI), blood pressure, fasting blood sugar (FBS), and lipid profiles, were extracted from medical records. Glycaemic outcomes were classified into three categories: reversion to normoglyacemia, persistent prediabetes, or progression to DM, based on glycated haemoglobin (HbA1c) levels taken within two years of follow-up. Ordinal logistic regression analysis was used to identify the significant predictors influencing these outcomes.

Results: Analysis showed age, BMI, underlying dyslipidaemia, FBS, and triglyceride levels as significant predictors of glycaemic progression. Specifically, each additional year of age and each one-unit increase in BMI raised the likelihood of progression to DM by 3% and 6%, respectively. Participants with dyslipidaemia were noted to have a 67% higher risk of worsening glycaemic status, while increases in FBS and triglyceride levels were associated with 65% and 34% greater odds of diabetic progression, respectively.

Conclusion: This study identifies critical predictors of glycaemic outcomes in prediabetic adults, emphasizing the role of age, BMI, dyslipidaemia, FBS, and triglycerides in the disease progression. These findings support the development of targeted interventions that address these risk factors to curb diabetes progression in high-risk individuals, contributing valuable insights into diabetes prevention strategies tailored for Malaysian populations.

确定糖尿病前期血糖结局恶化的预测因素:马来西亚登嘉楼的一项为期两年的队列研究。
前驱糖尿病是糖尿病(DM)前的一个关键阶段,它也与发生DM及相关并发症的风险升高有关。解决影响糖尿病前期个体血糖结局进展或消退的预测因素可以增强干预策略。本研究旨在确定马来西亚登嘉楼成人糖尿病前期患者血糖进展的关键预测因素。材料和方法:在2019年1月至2023年6月期间,对登嘉楼28家诊所的592名糖尿病前期成年人进行了回顾性队列研究。参与者的选择是基于口服葡萄糖耐量试验(OGTT)结果显示的前驱糖尿病。从医疗记录中提取社会人口统计学、医学背景和临床数据,包括体重指数(BMI)、血压、空腹血糖(FBS)和脂质谱。根据两年内随访的糖化血红蛋白(HbA1c)水平,将血糖结局分为三类:恢复到正常血糖、持续的糖尿病前期或进展为糖尿病。使用有序逻辑回归分析来确定影响这些结果的重要预测因素。结果:分析显示,年龄、BMI、潜在的血脂异常、FBS和甘油三酯水平是血糖进展的重要预测因素。具体来说,年龄每增加一岁,BMI每增加一个单位,发展为糖尿病的可能性分别增加3%和6%。血脂异常的参与者血糖状态恶化的风险增加67%,而FBS和甘油三酯水平的增加分别与糖尿病进展的风险增加65%和34%相关。结论:本研究确定了糖尿病前期成人血糖结局的关键预测因素,强调了年龄、BMI、血脂异常、FBS和甘油三酯在疾病进展中的作用。这些发现支持有针对性的干预措施的发展,解决这些风险因素,以遏制高风险人群的糖尿病进展,为为马来西亚人群量身定制的糖尿病预防策略提供有价值的见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Medical Journal of Malaysia
Medical Journal of Malaysia Medicine-Medicine (all)
CiteScore
1.20
自引率
0.00%
发文量
165
期刊介绍: Published since 1890 this journal originated as the Journal of the Straits Medical Association. With the formation of the Malaysian Medical Association (MMA), the Journal became the official organ, supervised by an editorial board. Some of the early Hon. Editors were Mr. H.M. McGladdery (1960 - 1964), Dr. A.A. Sandosham (1965 - 1977), Prof. Paul C.Y. Chen (1977 - 1987). It is a scientific journal, published quarterly and can be found in medical libraries in many parts of the world. The Journal also enjoys the status of being listed in the Index Medicus, the internationally accepted reference index of medical journals. The editorial columns often reflect the Association''s views and attitudes towards medical problems in the country. The MJM aims to be a peer reviewed scientific journal of the highest quality. We want to ensure that whatever data is published is true and any opinion expressed important to medical science. We believe being Malaysian is our unique niche; our priority will be for scientific knowledge about diseases found in Malaysia and for the practice of medicine in Malaysia. The MJM will archive knowledge about the changing pattern of human diseases and our endeavours to overcome them. It will also document how medicine develops as a profession in the nation. We will communicate and co-operate with other scientific journals in Malaysia. We seek articles that are of educational value to doctors. We will consider all unsolicited articles submitted to the journal and will commission distinguished Malaysians to write relevant review articles. We want to help doctors make better decisions and be good at judging the value of scientific data. We want to help doctors write better, to be articulate and precise.
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