{"title":"Free omental patch as the promising future for incisional hernia surgery: an experimental study in rat model.","authors":"I Sofii, I Widodo, Gunadi, A Y Handaya","doi":"","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Incisional hernia is the common complication of abdominal surgery with serious morbidity. The use of Composite mesh (CM) is the current gold standard, which is superior to Polypropylene mesh (PPM) for closing the defect, due to its minimal intraabdominal adhesion. In this study, we were using the novel combination of free omental patch (FOP) and PPM compared to CM for defect closure surgery in incisional hernia using rat models. We compared the gene expression of VEGF, COL3A1, COL1A1, COL1A2, and ratio of COL1A1/COL3A1 as the representative of wound healing process from all treatment options.</p><p><strong>Materials and methods: </strong>Eighteen wistar rats were made into incisional hernia models and divided into three groups of FOP, FOP-PPM, and CM at the 14th day. After each group underwent hernia repair, abdominal wall samples were taken to examine the expression of qPCR VEGF, COL3A1, COL1A1, and COL1A2 at the 21st day.</p><p><strong>Results: </strong>There were no significant different in the gene expression of VEGF, COL3A1, COL1A1, COL1A2 and COL1A1/COL3A1 ratio between FOP, FOP-PPM and CM group (p-value >0.05). In addition, non-significant result also found at the comparative analysis between FOP-PPM and MC groups.</p><p><strong>Conclusions: </strong>FOP can give the similar result as CM for defect closure surgery in incisional hernia, either when combined with PPM or as a single option. However, further clinical study is needed to support this animal study.</p>","PeriodicalId":39388,"journal":{"name":"Medical Journal of Malaysia","volume":"80 2","pages":"174-177"},"PeriodicalIF":0.0000,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medical Journal of Malaysia","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
Introduction: Incisional hernia is the common complication of abdominal surgery with serious morbidity. The use of Composite mesh (CM) is the current gold standard, which is superior to Polypropylene mesh (PPM) for closing the defect, due to its minimal intraabdominal adhesion. In this study, we were using the novel combination of free omental patch (FOP) and PPM compared to CM for defect closure surgery in incisional hernia using rat models. We compared the gene expression of VEGF, COL3A1, COL1A1, COL1A2, and ratio of COL1A1/COL3A1 as the representative of wound healing process from all treatment options.
Materials and methods: Eighteen wistar rats were made into incisional hernia models and divided into three groups of FOP, FOP-PPM, and CM at the 14th day. After each group underwent hernia repair, abdominal wall samples were taken to examine the expression of qPCR VEGF, COL3A1, COL1A1, and COL1A2 at the 21st day.
Results: There were no significant different in the gene expression of VEGF, COL3A1, COL1A1, COL1A2 and COL1A1/COL3A1 ratio between FOP, FOP-PPM and CM group (p-value >0.05). In addition, non-significant result also found at the comparative analysis between FOP-PPM and MC groups.
Conclusions: FOP can give the similar result as CM for defect closure surgery in incisional hernia, either when combined with PPM or as a single option. However, further clinical study is needed to support this animal study.
期刊介绍：
Published since 1890 this journal originated as the Journal of the Straits Medical Association. With the formation of the Malaysian Medical Association (MMA), the Journal became the official organ, supervised by an editorial board. Some of the early Hon. Editors were Mr. H.M. McGladdery (1960 - 1964), Dr. A.A. Sandosham (1965 - 1977), Prof. Paul C.Y. Chen (1977 - 1987). It is a scientific journal, published quarterly and can be found in medical libraries in many parts of the world. The Journal also enjoys the status of being listed in the Index Medicus, the internationally accepted reference index of medical journals. The editorial columns often reflect the Association''s views and attitudes towards medical problems in the country. The MJM aims to be a peer reviewed scientific journal of the highest quality. We want to ensure that whatever data is published is true and any opinion expressed important to medical science. We believe being Malaysian is our unique niche; our priority will be for scientific knowledge about diseases found in Malaysia and for the practice of medicine in Malaysia. The MJM will archive knowledge about the changing pattern of human diseases and our endeavours to overcome them. It will also document how medicine develops as a profession in the nation. We will communicate and co-operate with other scientific journals in Malaysia. We seek articles that are of educational value to doctors. We will consider all unsolicited articles submitted to the journal and will commission distinguished Malaysians to write relevant review articles. We want to help doctors make better decisions and be good at judging the value of scientific data. We want to help doctors write better, to be articulate and precise.
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