The mouse resource at National Resource Center for Mutant Mice of China.

IF 2.7 4区 生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
Bingzhou Han, Dongshen Chen, Zhong Chen, Ting Wang, Kaiyuan Zi, Rui Feng, Xiaoliu Yang, Ling'en Li, Juan Liang, Xiang Gao
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引用次数: 0

Abstract

Mouse models serve as the most important laboratory resource for both biomedical research and preclinical study of drug development. National Resource Center of Mutant Mice (NRCMM) of China was initiated in 2001 and became one of the 31 members of National Science and Technology Resource Sharing Platform in 2019. Currently, NRCMM is co-managed by Model Animal Research Center of Nanjing University and Gempharmatech (GPT, a Shanghai Exchange enlisted public company). Dedicated to produce and collect genetic edited mouse models, NRCMM holds more than 22,000 mouse strains in 2024, compared with 18,500 strains reported in 2022. This review provides an update on our Knock-Out All Project (KOAP) and highlights resources available for immune system reconstitution models, disease models, and chromosome substitution strains at NRCMM.

中国国家突变小鼠资源中心的小鼠资源。
小鼠模型是生物医学研究和药物开发临床前研究最重要的实验室资源。中国国家突变小鼠资源中心成立于2001年,2019年成为国家科技资源共享平台31家成员单位之一。目前,NRCMM由南京大学模型动物研究中心和Gempharmatech (GPT,上海证券交易所上市公司)共同管理。NRCMM致力于生产和收集基因编辑的小鼠模型,2024年拥有超过2.2万个小鼠品系,而2022年报告的品系为18500个。这篇综述提供了我们的全敲除项目(KOAP)的最新进展,并重点介绍了nrcm免疫系统重建模型、疾病模型和染色体替代菌株的可用资源。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Mammalian Genome
Mammalian Genome 生物-生化与分子生物学
CiteScore
4.00
自引率
0.00%
发文量
33
审稿时长
6-12 weeks
期刊介绍: Mammalian Genome focuses on the experimental, theoretical and technical aspects of genetics, genomics, epigenetics and systems biology in mouse, human and other mammalian species, with an emphasis on the relationship between genotype and phenotype, elucidation of biological and disease pathways as well as experimental aspects of interventions, therapeutics, and precision medicine. The journal aims to publish high quality original papers that present novel findings in all areas of mammalian genetic research as well as review articles on areas of topical interest. The journal will also feature commentaries and editorials to inform readers of breakthrough discoveries as well as issues of research standards, policies and ethics.
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