Clinical Features and Patient-Reported Outcomes in a Cohort of Patients with Sjögren's Disease.

IF 3 3区 医学 Q1 MEDICINE, GENERAL & INTERNAL
Rossana Izzetti, Chiara Cinquini, Giovanni Fulvio, Marco Nisi, Chiara Baldini, Antonio Barone
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Abstract

Background: Sjögren's disease (SD) is an autoimmune condition causing progressive salivary and lacrimal glands dysfunction following lymphocytic infiltration in the glandular tissue. SD patients are more prone to oral health impairment due to a reduction in salivary flow. This study evaluated the relationship between oral health, functional tests, and patient reported outcomes in a cohort of SD patients. Methods: Patients diagnosed with SD underwent complete dental examination, with the recording of the decayed-missing-filled teeth index (DMFT), probing pocket depth (PPD), full mouth bleeding score (FMBS), and full mouth plaque score (FMPS). Hyposalivation was assessed using the unstimulated whole saliva flow rate (UWS). Patients were administered the European League Against Rheumatism (EULAR) Sjögren's Syndrome Patient Reported Index, EULAR Sjögren's syndrome disease activity index, Oral Health Impact Profile-14 (OHIP-14), Patient Acceptable Symptom State questionnaires, and a visual analog scale for xerostomia (VASx). Results: Fifty patients in total were enrolled. Reduced UWS was associated with higher DMFT, FMBS, and FMPS. Significant correlation was observed for UWS with VASx and OHIP-14 (p < 0.05). Conclusions: Quality of life and oral health appear mildly impaired in SD patients as an effect of reduced salivary flow, with higher DMFT and tendency towards gingival inflammation and plaque accumulation.

Sjögren病患者队列的临床特征和患者报告的结果
背景:Sjögren病(SD)是一种自身免疫性疾病,引起腺体组织淋巴细胞浸润后进行性唾液腺和泪腺功能障碍。由于唾液流量减少,SD患者更容易出现口腔健康损害。本研究在一组SD患者中评估了口腔健康、功能测试和患者报告结果之间的关系。方法:对诊断为SD的患者进行完整的口腔检查,记录龋缺补牙指数(DMFT)、探牙袋深度(PPD)、全口出血评分(FMBS)、全口菌斑评分(FMPS)。使用未受刺激的全唾液流率(UWS)评估低唾液化。患者接受欧洲抗风湿病联盟(EULAR) Sjögren综合征患者报告指数、EULAR Sjögren综合征疾病活动指数、口腔健康影响概况-14 (o嘻哈-14)、患者可接受症状状态问卷调查和口干视觉模拟量表(VASx)。结果:共纳入50例患者。减少的UWS与较高的DMFT、FMBS和FMPS相关。UWS与VASx、OHIP-14有显著相关性(p < 0.05)。结论:SD患者的生活质量和口腔健康表现为轻度受损,这是唾液流量减少的影响,DMFT较高,牙龈炎症和牙菌斑积聚的倾向。
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来源期刊
Journal of Clinical Medicine
Journal of Clinical Medicine MEDICINE, GENERAL & INTERNAL-
CiteScore
5.70
自引率
7.70%
发文量
6468
审稿时长
16.32 days
期刊介绍: Journal of Clinical Medicine (ISSN 2077-0383), is an international scientific open access journal, providing a platform for advances in health care/clinical practices, the study of direct observation of patients and general medical research. This multi-disciplinary journal is aimed at a wide audience of medical researchers and healthcare professionals. Unique features of this journal: manuscripts regarding original research and ideas will be particularly welcomed.JCM also accepts reviews, communications, and short notes. There is no limit to publication length: our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible.
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