{"title":"Can partial cardiac denervation reduce postoperative atrial fibrillation following CABG?","authors":"Hamrish Kumar Rajakumar","doi":"10.1007/s12055-025-01929-4","DOIUrl":null,"url":null,"abstract":"<p><p>This article provides a critical appraisal of the partial cardiac denervation-postoperative atrial fibrillation (pCAD-POAF) randomized clinical trial, which investigates the effectiveness of partial cardiac denervation in reducing POAF in patients undergoing coronary artery bypass grafting (CABG). The trial demonstrated a significant reduction in POAF incidence in the intervention group compared to the control group. Despite promising results, the study has several limitations, including the exclusion of high-risk patients with advanced comorbidities and a short follow-up period, which restricts the generalizability of the findings. This appraisal examines the trial's strengths, such as its novel approach and statistical design, while addressing areas for improvement. Future research should focus on long-term outcomes, broader patient inclusion, and the incorporation of health-related quality of life assessments.</p>","PeriodicalId":13285,"journal":{"name":"Indian Journal of Thoracic and Cardiovascular Surgery","volume":"41 4","pages":"493-497"},"PeriodicalIF":0.7000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11933557/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Indian Journal of Thoracic and Cardiovascular Surgery","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s12055-025-01929-4","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/3/5 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
引用次数: 0
Abstract
This article provides a critical appraisal of the partial cardiac denervation-postoperative atrial fibrillation (pCAD-POAF) randomized clinical trial, which investigates the effectiveness of partial cardiac denervation in reducing POAF in patients undergoing coronary artery bypass grafting (CABG). The trial demonstrated a significant reduction in POAF incidence in the intervention group compared to the control group. Despite promising results, the study has several limitations, including the exclusion of high-risk patients with advanced comorbidities and a short follow-up period, which restricts the generalizability of the findings. This appraisal examines the trial's strengths, such as its novel approach and statistical design, while addressing areas for improvement. Future research should focus on long-term outcomes, broader patient inclusion, and the incorporation of health-related quality of life assessments.
期刊介绍：
The primary aim of the Indian Journal of Thoracic and Cardiovascular Surgery is education. The journal aims to dissipate current clinical practices and developments in the area of cardiovascular and thoracic surgery. This includes information on cardiovascular epidemiology, aetiopathogenesis, clinical manifestation etc. The journal accepts manuscripts from cardiovascular anaesthesia, cardiothoracic and vascular nursing and technology development and new/innovative products.The journal is the official publication of the Indian Association of Cardiovascular and Thoracic Surgeons which has a membership of over 1000 at present.DescriptionThe journal is the official organ of the Indian Association of Cardiovascular-Thoracic Surgeons. It was started in 1982 by Dr. Solomon Victor and ws being published twice a year up to 1996. From 2000 the editorial office moved to Delhi. From 2001 the journal was extended to quarterly and subsequently four issues annually have been printed out at time and regularly without fail. The journal receives manuscripts from members and non-members and cardiovascular surgeons. The manuscripts are peer reviewed by at least two or sometimes three or four reviewers who are on the panel. The manuscript process is now completely online. Funding the journal comes partially from the organization and from revenue generated by subscription and advertisement.
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