Adult leukemia in Florida 2010-2019: diverse, aging population as an indicator for the United States

Ming S. Lee ∗ , Rebecca E. Kaiser ∗ , Christopher D. Armstrong , David B. Dukenik , Nancy S. Elliott , Raymond R. Balise , Justin M. Watts , Mikkael A. Sekeres , Erin N. Kobetz , Justin Taylor
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Abstract

According to recent data released by the National Cancer Institute, Florida has the highest incidence of adult leukemia in the United States. There is limited population-based research on aging and sociodemographic disparities associated with leukemia in Florida, which can have a national impact on the assessment of leukemia burden. Using geocoded cancer data from the Florida Cancer Data System and population data from the US Census, this study evaluated socioeconomic and regional disparities associated with leukemia and found that leukemia disparities by race/ethnicity and rurality exist in Florida. The non-Hispanic White population had the highest incidence rates for most subtypes of leukemia, whereas the non-Hispanic Black population had the highest odds of dying from leukemia. Rural counties and urban neighborhoods with lower socioeconomic status were associated with higher mortality odds for leukemia. Leukemia-treating physician numbers were mismatched in regions in which patients with leukemia exhibit higher incidence and mortality odds. These results suggest that leukemia incidence rate in Florida is likely to remain among the highest in the United States due to population aging; however, physician shortages may exacerbate disparities and limit care in rural areas. Florida demographically looks like what the entire US population may be in the future and is therefore an indicator of the coming needs in the United States for increased leukemia diagnosis, treatment, and survivorship care. Larger national and international studies can build on this study by applying our methodology on a larger scale and can also be applied to other hematologic malignancies and other cancer types.
佛罗里达州2010-2019年成人白血病:人口老龄化是美国的一个指标
摘要根据美国国家癌症研究所最近公布的数据,佛罗里达州是美国成人白血病发病率最高的州。在佛罗里达州,关于与白血病相关的老龄化和社会人口统计学差异的基于人群的研究有限,这可能对白血病负担的评估产生全国性影响。利用佛罗里达癌症数据系统的地理编码癌症数据和美国人口普查的人口数据,本研究评估了与白血病相关的社会经济和地区差异,并发现佛罗里达州存在种族/民族和农村地区的白血病差异。非西班牙裔白人在大多数白血病亚型中发病率最高,而非西班牙裔黑人死于白血病的几率最高。社会经济地位较低的农村县和城市社区患白血病的死亡率较高。在白血病患者发病率和死亡率较高的地区,治疗白血病的医生数量不匹配。这些结果表明,由于人口老龄化,佛罗里达州的白血病发病率可能仍然是美国最高的;然而,医生短缺可能会加剧差距,限制农村地区的医疗服务。佛罗里达州的人口统计数据与未来整个美国人口的情况相似,因此,这是美国对白血病诊断、治疗和生存护理需求增加的一个指标。通过在更大范围内应用我们的方法,更大规模的国内和国际研究可以建立在这项研究的基础上,也可以应用于其他血液恶性肿瘤和其他癌症类型。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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