Exploring finetuned audio-LLM on heart murmur features

Abstract

Large language models (LLMs) for audio have excelled in recognizing and analyzing human speech, music, and environmental sounds. However, their potential for understanding other types of sounds, particularly biomedical sounds, remains largely underexplored despite significant scientific interest. In this study, we focus on diagnosing cardiovascular diseases using phonocardiograms, i.e., heart sounds. Most existing deep neural network (DNN) paradigms are restricted to heart murmur classification (healthy vs unhealthy) and do not predict other acoustic features of the murmur such as grading, harshness, pitch, and quality, which are important in helping physicians diagnose the underlying heart conditions. We propose to finetune an audio LLM, Qwen2-Audio, on the PhysioNet CirCor DigiScope phonocardiogram (PCG) dataset and evaluate its performance in classifying 11 expert-labeled features. Additionally, we aim to achieve more noise-robust and generalizable system by exploring a preprocessing segmentation algorithm using an audio representation model, SSAMBA. Our results indicate that the LLM-based model outperforms state-of-the-art methods in 10 of the 11 tasks. Moreover, the LLM successfully classifies long-tail features with limited training data, a task that all previous methods have failed to classify. These findings underscore the potential of audio LLMs as assistants to human cardiologists in enhancing heart disease diagnosis.