C. elegans wired and wireless connectome: insights into principles of nervous system structure and function.

IF 2.1 4区 生物学 Q2 BIOLOGY
Journal of Biosciences Pub Date : 2025-01-01
Keertana Venkatesh, Lidia Ripoll -Sánchez, Isabel Beets, William R Schafer
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引用次数: 0

Abstract

Caenorhabditis elegans is one of the primary model organisms for neuroscience research due to its well annotated and compact nervous system. Being the first organism with a mapped connectome, published nearly 40 years ago, it holds a critical place in the field of neuroscience. Over the past decades, exhaustive mapping of the C. elegans nervous system at the molecular and cellular level, along with the development of tools to probe neural dynamics, have given invaluable insights on neuronal communication at the cellular, circuit, and systems level. In this review, we discuss key features of the C. elegans connectome, the wired (synaptic) as well as the wireless (extrasynaptic) network, and their role in executing complex behaviours. We delve into recent advances in C. elegans neuroscience, highlighting how in vivo and in silico studies have elucidated functional principles that govern sensory integration and the importance of assessing behavioural features at a systems level. With emerging connectomes of other, more complex organisms, this field offers a robust framework for testable hypotheses and comparative connectomics.

秀丽隐杆线虫有线和无线连接组:对神经系统结构和功能原理的见解。
秀丽隐杆线虫是神经科学研究的主要模式生物之一,因为它的神经系统被很好地注释和紧凑。作为第一个拥有连接体图谱的生物,它在近40年前发表,在神经科学领域占有重要地位。在过去的几十年里,秀丽隐杆线虫神经系统在分子和细胞水平上的详尽映射,以及探测神经动力学的工具的发展,已经在细胞、电路和系统水平上对神经元通信提供了宝贵的见解。在这篇综述中,我们讨论了秀丽隐杆线虫连接组的主要特征,有线(突触)和无线(突触外)网络,以及它们在执行复杂行为中的作用。我们深入研究了秀丽隐杆线虫神经科学的最新进展,强调了体内和计算机研究如何阐明了控制感觉统合的功能原理,以及在系统水平上评估行为特征的重要性。随着其他更复杂生物的连接组的出现,这一领域为可测试的假设和比较连接组学提供了一个强大的框架。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Biosciences
Journal of Biosciences 生物-生物学
CiteScore
5.80
自引率
0.00%
发文量
83
审稿时长
3 months
期刊介绍: The Journal of Biosciences is a quarterly journal published by the Indian Academy of Sciences, Bangalore. It covers all areas of Biology and is the premier journal in the country within its scope. It is indexed in Current Contents and other standard Biological and Medical databases. The Journal of Biosciences began in 1934 as the Proceedings of the Indian Academy of Sciences (Section B). This continued until 1978 when it was split into three parts : Proceedings-Animal Sciences, Proceedings-Plant Sciences and Proceedings-Experimental Biology. Proceedings-Experimental Biology was renamed Journal of Biosciences in 1979; and in 1991, Proceedings-Animal Sciences and Proceedings-Plant Sciences merged with it.
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