Ömer Faruk Turan, Nurullah İshak Işık, Safa Dönmez, Hamdi Haluk Çalı, Kasım Ateş, Feyza Baysar, Lukasz Szarpak, Jacek Smereka, Burak Katipoğlu
{"title":"Prognostic Value of Biomarkers in Acute Aortic Dissection: Analysis of Clinical Outcomes and Mortality.","authors":"Ömer Faruk Turan, Nurullah İshak Işık, Safa Dönmez, Hamdi Haluk Çalı, Kasım Ateş, Feyza Baysar, Lukasz Szarpak, Jacek Smereka, Burak Katipoğlu","doi":"10.1155/emmi/6664490","DOIUrl":null,"url":null,"abstract":"<p><p><b>Introduction:</b> Acute aortic dissection (AAD) is a severe condition requiring immediate diagnosis and treatment to reduce high mortality rates. This study investigates laboratory markers that may support the diagnostic process and predict surgical outcomes and mortality in AAD patients. <b>Materials and Methods:</b> This retrospective study analyzed data from 85 patients diagnosed with AAD in an emergency setting. Patients over 18 years of age with a diagnosis of acute dissection were included. Key laboratory and clinical parameters were examined to determine their association with mortality and the likelihood of surgical intervention. <b>Results:</b> The study found that younger patients were more likely to undergo surgery, while parameters such as white blood cells (WBCs), neutrophil, and lymphocyte counts were elevated in those undergoing surgery. Mortality predictors included elevated mean platelet volume (MPV), low pH, bicarbonate (HCO<sub>3</sub>), and base deficit levels. Each unit increase in MPV was associated with a threefold increase in mortality risk, and DeBakey Type 1 patients exhibited the highest MPV levels. <b>Discussion:</b> WBC and MPV values were linked with surgical and mortality outcomes, respectively. Blood gas analysis parameters, particularly HCO<sub>3</sub> and base deficit levels, were significant mortality predictors, underscoring the importance of metabolic markers in AAD assessment. The findings suggest that incorporating these laboratory parameters into diagnostic and treatment decisions could improve AAD management.</p>","PeriodicalId":11528,"journal":{"name":"Emergency Medicine International","volume":"2025 ","pages":"6664490"},"PeriodicalIF":1.2000,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11936519/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Emergency Medicine International","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1155/emmi/6664490","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"EMERGENCY MEDICINE","Score":null,"Total":0}
引用次数: 0
Abstract
Introduction: Acute aortic dissection (AAD) is a severe condition requiring immediate diagnosis and treatment to reduce high mortality rates. This study investigates laboratory markers that may support the diagnostic process and predict surgical outcomes and mortality in AAD patients. Materials and Methods: This retrospective study analyzed data from 85 patients diagnosed with AAD in an emergency setting. Patients over 18 years of age with a diagnosis of acute dissection were included. Key laboratory and clinical parameters were examined to determine their association with mortality and the likelihood of surgical intervention. Results: The study found that younger patients were more likely to undergo surgery, while parameters such as white blood cells (WBCs), neutrophil, and lymphocyte counts were elevated in those undergoing surgery. Mortality predictors included elevated mean platelet volume (MPV), low pH, bicarbonate (HCO3), and base deficit levels. Each unit increase in MPV was associated with a threefold increase in mortality risk, and DeBakey Type 1 patients exhibited the highest MPV levels. Discussion: WBC and MPV values were linked with surgical and mortality outcomes, respectively. Blood gas analysis parameters, particularly HCO3 and base deficit levels, were significant mortality predictors, underscoring the importance of metabolic markers in AAD assessment. The findings suggest that incorporating these laboratory parameters into diagnostic and treatment decisions could improve AAD management.
期刊介绍:
Emergency Medicine International is a peer-reviewed, Open Access journal that provides a forum for doctors, nurses, paramedics and ambulance staff. The journal publishes original research articles, review articles, and clinical studies related to prehospital care, disaster preparedness and response, acute medical and paediatric emergencies, critical care, sports medicine, wound care, and toxicology.