Innovation in Osteogenesis Activation: Role of Marine-Derived Materials in Bone Regeneration.

IF 2.8 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Current Issues in Molecular Biology Pub Date : 2025-03-07 DOI:10.3390/cimb47030175

Maria Giovanna Rizzo, Marilena Briglia, Vincenzo Zammuto, Dario Morganti, Caterina Faggio, Federica Impellitteri, Cristiana Roberta Multisanti, Adriana Carol Eleonora Graziano

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引用次数: 0

Abstract

Marine-derived biomaterials are emerging as promising candidates for tissue regeneration due to their sustainability, biocompatibility, bioactivity, and unique chemical structure. This review provides an overview of different marine-derived inorganic and organic materials, such as calcium carbonate, magnesium salts, silica, polysaccharides, bioactive peptides, and lipid-based compounds, and their effects in promoting osteogenesis. Specifically, the osteoinductive, osteoconductive, and osteointegrative activities of traditional and innovative materials that influence key molecular pathways such as BMP/Smad and Wnt/β-catenin signaling underlying bone formation will be evaluated. This review also prospects innovative approaches, i.e., phage display technology, to optimize marine-derived peptides for targeted bone regeneration. In the context of innovative and sustainable materials, this review suggests some interesting applications of unusual materials able to overcome the limitations of conventional ones and stimulate cellular regeneration of bone tissue by activating specific molecular pathways.

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骨生成激活的创新：海洋材料在骨再生中的作用。

海洋生物材料因其可持续性、生物相容性、生物活性和独特的化学结构，正逐渐成为组织再生的理想候选材料。本综述概述了不同的海洋衍生无机和有机材料，如碳酸钙、镁盐、二氧化硅、多糖、生物活性肽和脂基化合物，以及它们在促进骨生成方面的作用。具体而言，将评估传统材料和创新材料的诱导骨生成、诱导骨生成和骨整合活性，这些活性会影响骨形成的关键分子通路，如 BMP/Smad 和 Wnt/β-catenin 信号传导。本综述还展望了创新方法，即噬菌体展示技术，以优化海洋衍生肽，实现有针对性的骨再生。在创新和可持续材料方面，这篇综述提出了一些不同寻常的材料的有趣应用，这些材料能够克服传统材料的局限性，并通过激活特定的分子途径刺激骨组织的细胞再生。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Issues in Molecular Biology 生物-生化研究方法

CiteScore

2.90

自引率

3.20%

发文量

380

审稿时长

>12 weeks

期刊介绍： Current Issues in Molecular Biology (CIMB) is a peer-reviewed journal publishing review articles and minireviews in all areas of molecular biology and microbiology. Submitted articles are subject to an Article Processing Charge (APC) and are open access immediately upon publication. All manuscripts undergo a peer-review process.