Abdulmalik Saleem, Murtaza Hussain, Shula Schechter, Matthew B Sturm
{"title":"Colonic malakoplakia.","authors":"Abdulmalik Saleem, Murtaza Hussain, Shula Schechter, Matthew B Sturm","doi":"10.1136/bcr-2025-265174","DOIUrl":null,"url":null,"abstract":"<p><p>Colonic malakoplakia is a rare granulomatous inflammatory condition that can cause abdominal pain, diarrhoea and rectal bleeding and be associated with colon adenocarcinoma. Chronic bacterial infections with defective lysosomal activity in macrophages are possible causes for malakoplakia. We present a case report of asymptomatic colonic malakoplakia in an otherwise healthy woman undergoing a screening colonoscopy for colorectal cancer. Limited case reports and treatment guidance are available for colonic malakoplakia with only a few dozen cases in the literature. Given the potential morbidity and mortality associated with this condition, we emphasise the importance of thorough diagnostic and therapeutic evaluation even in asymptomatic patients.</p>","PeriodicalId":9080,"journal":{"name":"BMJ Case Reports","volume":"18 3","pages":""},"PeriodicalIF":0.6000,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"BMJ Case Reports","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1136/bcr-2025-265174","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0
Abstract
Colonic malakoplakia is a rare granulomatous inflammatory condition that can cause abdominal pain, diarrhoea and rectal bleeding and be associated with colon adenocarcinoma. Chronic bacterial infections with defective lysosomal activity in macrophages are possible causes for malakoplakia. We present a case report of asymptomatic colonic malakoplakia in an otherwise healthy woman undergoing a screening colonoscopy for colorectal cancer. Limited case reports and treatment guidance are available for colonic malakoplakia with only a few dozen cases in the literature. Given the potential morbidity and mortality associated with this condition, we emphasise the importance of thorough diagnostic and therapeutic evaluation even in asymptomatic patients.
期刊介绍：
BMJ Case Reports is an important educational resource offering a high volume of cases in all disciplines so that healthcare professionals, researchers and others can easily find clinically important information on common and rare conditions. All articles are peer reviewed and copy edited before publication. BMJ Case Reports is not an edition or supplement of the BMJ.
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