The role of calcium signaling in organotropic metastasis of cancer.

IF 6.9 1区医学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Acta Pharmacologica Sinica Pub Date : 2025-07-01 Epub Date: 2025-03-25 DOI:10.1038/s41401-025-01537-3

Yong-Hao Li, Chu-Run Zheng, Yue Liu, Ke Wang, Fan-Fan Zhou, Xin Dong, Tao Yuan, Qiao-Jun He, Hong Zhu, Bo Yang

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引用次数: 0

Abstract

Tumor metastasis is an important event in cancer progression, representing an enduring and irrevocable hallmark of cancers. The causes of tumor metastasis are complex and diverse. Arising evidence shows that the dysregulation of calcium signaling plays a crucial role in its initiation and progress. Calcium is an essential secondary messenger that regulates signaling pathways associated with tumor metastasis. The transient accumulation of calcium potentially promotes the advancement of tumor metastasis, while calcium-dependent proteins and calcium-related channels also significantly contribute to such malignant process. Thus, compounds specially targeting calcium channels, transporters or pumps may be therapeutic approaches prohibiting tumor metastasis. This review focuses on exploring the roles of calcium ions, calcium-dependent proteins and calcium-related channels in organotropic metastasis of cancer and its clinical applications in the treatment of metastatic cancers.

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钙信号在肿瘤嗜器官转移中的作用。

肿瘤转移是癌症进展中的一个重要事件，代表了癌症的持久和不可逆转的标志。肿瘤转移的原因复杂多样。越来越多的证据表明，钙信号的失调在其发生和发展中起着至关重要的作用。钙是调节肿瘤转移相关信号通路的重要次生信使。钙的短暂积累可能促进肿瘤转移的进程，而钙依赖蛋白和钙相关通道也显著促进了这种恶性过程。因此，专门针对钙通道、转运体或泵的化合物可能是阻止肿瘤转移的治疗途径。本文就钙离子、钙依赖蛋白和钙相关通道在肿瘤嗜器官转移中的作用及其在转移性肿瘤治疗中的临床应用作一综述。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Pharmacologica Sinica 医学-化学综合

CiteScore

15.10

自引率

2.40%

发文量

4365

审稿时长

2 months

期刊介绍： APS (Acta Pharmacologica Sinica) welcomes submissions from diverse areas of pharmacology and the life sciences. While we encourage contributions across a broad spectrum, topics of particular interest include, but are not limited to: anticancer pharmacology, cardiovascular and pulmonary pharmacology, clinical pharmacology, drug discovery, gastrointestinal and hepatic pharmacology, genitourinary, renal, and endocrine pharmacology, immunopharmacology and inflammation, molecular and cellular pharmacology, neuropharmacology, pharmaceutics, and pharmacokinetics. Join us in sharing your research and insights in pharmacology and the life sciences.