Design, Development and Evaluation of Polyherbal Lollipops Formulation for the Treatment of Oral Thrush and Periodontal Disease

IF 2.7 4区医学 Q2 PHARMACOLOGY & PHARMACY

Journal of Pharmaceutical Innovation Pub Date : 2025-03-26 DOI:10.1007/s12247-025-09970-x

Rushikesh Kshirsagar, Varsha Balkrishna Mane, Nagesh Aloorkar, Divya Bhagat, Sanuja Kadam, Sagar Pathade

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引用次数: 0

Abstract

Purpose

The present investigation aims to formulate a polyherbal lollipops incorporating Neem (Azadirachta indica), Clove (Syzygium aromaticum), Ginger (Zingiber officinale) extract to combat dental problems of Oral Thrush and Periodontal Disease.

Methods

Such lollipops were successfully prepared by using heating and congealing method using 23 full factorial design approach. Sucrose, Methyl Cellulose and corn syrup were considered as independent variables and their effect was studied on Hardness, drug release and disintegration time considering as a dependent variable.

Result

The optimized formulation was found to be symmetrical, smooth, and clear with shiny surfaces and no inconsistencies. The hardness and disintegration time of formulation with increasing concentration ranges between 6 (Kg/cm.sq) -14 (Kg/cm.sq) and 7.56 min to 14.11 min. whereas the drug release was found in between 25.34 ± 2.3% to 89.01 ± 1.9%. After evaluating formulation it has been found that level of independent variables positively affects the Hardness and disintegration time while negatively affects drug release.

Conclusion

The formulation showed enhanced antifungal (candida albicans) and anti-bacterial (streptococcus mutans) activities when compared with standard drugs of Ketoconazole and Erythromycin respectively.

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来源期刊

Journal of Pharmaceutical Innovation PHARMACOLOGY & PHARMACY-

CiteScore

3.70

自引率

3.80%

发文量

审稿时长

>12 weeks

期刊介绍： The Journal of Pharmaceutical Innovation (JPI), is an international, multidisciplinary peer-reviewed scientific journal dedicated to publishing high quality papers emphasizing innovative research and applied technologies within the pharmaceutical and biotechnology industries. JPI''s goal is to be the premier communication vehicle for the critical body of knowledge that is needed for scientific evolution and technical innovation, from R&D to market. Topics will fall under the following categories: Materials science, Product design, Process design, optimization, automation and control, Facilities; Information management, Regulatory policy and strategy, Supply chain developments , Education and professional development, Journal of Pharmaceutical Innovation publishes four issues a year.