Anti-inflammatory potential of quercetin: From chemistry and mechanistic insight to nanoformulations

Q2 Agricultural and Biological Sciences
Diwakar Aggarwal , Mayank Chaudhary , Sachin Kumar Mandotra , Hardeep Singh Tuli , Ritu Chauhan , Naveen Chandra Joshi , Damandeep Kaur , Laurent Dufossé , Abhishek Chauhan
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引用次数: 0

Abstract

Flavonoids are hydroxylated polyphenols that are abundantly produced by plants as secondary metabolites. These flavonoids hold vast therapeutic potential as they possess numerous medicinal benefits encompassing anti-inflammatory, anti-oxidative, anticancer and antiviral properties. Flavonoids render anti-inflammatory effect either by activating antioxidant pathways or by inhibiting enzymatic secretions involved in inflammatory reactions. Flavonoids like quercetin targets inflammation by modulating expression of cytokines and pro-inflammatory molecules and by inhibiting pro-inflammatory enzymes. Mode of action, absorption and bioavailability of flavonoids greatly affect their biological activity. On-going research is focussing on isolation, synthesis of flavonoid analogs and effect of flavonoids on human health by manifestation of different techniques and animal models. Unravelling the anti-inflammatory potential of flavonoids can manifest better treatment options against variety of diseases and metabolic syndromes. Additionally, enhanced bioavailability of flavonoids can result in superior pharmaceutical activities.

Abstract Image

槲皮素的抗炎潜能:从化学和机理洞察到纳米配方
黄酮类化合物是一种羟基化的多酚,是植物大量产生的次生代谢产物。这些类黄酮具有巨大的治疗潜力,因为它们具有多种药用价值,包括抗炎、抗氧化、抗癌和抗病毒特性。黄酮类化合物通过激活抗氧化途径或抑制参与炎症反应的酶分泌来发挥抗炎作用。类黄酮如槲皮素通过调节细胞因子和促炎分子的表达以及抑制促炎酶来靶向炎症。黄酮类化合物的作用方式、吸收和生物利用度对其生物活性有很大影响。目前正在进行的研究主要集中在类黄酮类似物的分离、合成和类黄酮对人体健康的影响,通过不同的技术和动物模型的表现。揭示类黄酮的抗炎潜能,可以为多种疾病和代谢综合征提供更好的治疗选择。此外,提高黄酮类化合物的生物利用度可以导致优越的药物活性。
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来源期刊
Current Research in Pharmacology and Drug Discovery
Current Research in Pharmacology and Drug Discovery Agricultural and Biological Sciences-Animal Science and Zoology
CiteScore
6.40
自引率
0.00%
发文量
65
审稿时长
40 days
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