The Potential of Chronic Remote Ischemic Conditioning in Cerebral Small Vessel Disease.

Conditioning medicine Pub Date : 2024-02-01
David C Hess, Askiel Bruno, Mohammad B Khan, Pradip Kamat, Rolf Ankerlund Blauenfeldt, Janne Kaergard Mortensen, Grethe Andersen, Wenbo Zhao, Xunming Ji
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Abstract

Chronic remote ischemic conditioning (C-RIC) is the month-long or more intervention of RIC. C-RIC has shown promise in a large randomized clinical trial in intracranial atherosclerotic stenosis (ICAS) to reduce the risk of stroke. C-RIC has the potential to reduce cognitive impairment in cerebral small vessel disease (cSVD). C-RIC is effective in a preclinical model of vascular cognitive impairment and dementia (VCID), the bilateral carotid stenosis model in mice, at reducing cognitive impairment, and white matter damage. C-RIC is safe and shows promise in pilot clinical trials of cSVD. In cohort studies, physical exercise is effective at preventing stroke in ICAS and in slowing the progression of cognitive decline in cSVD. C-RIC shares common mechanisms with physical exercise and is an attractive therapy for cSVD. Dosing and compliance are two issues that need to be resolved before large phase II-III trials in cSVD can be optimized.

脑血管疾病慢性远端缺血调节的潜力。
慢性远端缺血适应(C-RIC)是一个月或更长时间的慢性远端缺血适应干预。在一项针对颅内动脉粥样硬化性狭窄(ICAS)的大型随机临床试验中,C-RIC显示出降低卒中风险的希望。C-RIC有可能减少脑血管疾病(cSVD)的认知障碍。C-RIC在血管性认知障碍和痴呆(VCID)的临床前模型、小鼠双侧颈动脉狭窄模型中,在减少认知障碍和白质损伤方面是有效的。C-RIC是安全的,在心血管疾病的试点临床试验中显示出前景。在队列研究中,体育锻炼可以有效地预防ICAS患者中风,并减缓心血管疾病患者认知能力下降的进展。C-RIC与体育锻炼有共同的机制,是一种有吸引力的心血管疾病治疗方法。在优化cSVD的大型II-III期试验之前,剂量和依从性是需要解决的两个问题。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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